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Ezutromid

Name: Ezutromid
Brand: TargetMol
SKU: T3424
Price: 170 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.76%

货号 T3424Cas号 945531-77-1

别名 依珠曲米, VOX-C1100, SMT C1100, BMN 195

Ezutromid (BMN 195) 是一种具有口服活性的、首创的苯并恶唑 utrophin 调节剂，EC50=0.91 μM。它抑制人肝微粒体 CYP1A2 酶活性，IC50=5.4 μM。它可用于 Duchenne 型肌营养不良症 (DMD) 的研究。

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Ezutromid

一键复制产品信息

很棒

纯度: 99.76%

货号 T3424 别名 依珠曲米, VOX-C1100, SMT C1100, BMN 195Cas号 945531-77-1

规格	价格	库存
1 mg	¥ 170	现货
5 mg	¥ 398	现货
10 mg	¥ 636	现货
25 mg	¥ 1,270	现货
50 mg	¥ 2,030	现货
100 mg	¥ 3,270	现货
200 mg	¥ 4,490	现货
1 mL x 10 mM (in DMSO)	¥ 437	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.76%

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COA HNMR LCMS 产品操作手册

产品介绍

Ezutromid AI Summary

Ezutromid activates the UTRN promoter leading to upregulation of utrophin production in mouse H2K cells, with an EC50 of 910.0 nM. At 10 µM, it activates the UTRN promoter to 143.0% after 72 hours. In CD1 mice, a 50 mg/kg intraperitoneal dose results in a Cmax of 4404.27 nM, Tmax of 0.25 hours, and an AUC of 420000.0 ng.hr.mL-1. It has a half-life of 1.358 hours in mouse liver microsomes and 1.75 hours in human liver microsomes. The compound demonstrates high aqueous solubility (3000.0 nM) and significant plasma protein binding in both mouse and human plasma. Additionally, Ezutromid exhibits modulation of human utrophinA expression in mouse cells with an EC50 of 187.0 nM and induces CYP2B and CYP1A1/2 enzymes, increasing PROD and EROD activity in minipigs. It also shows inhibition of CYP1A2 in human liver microsomes and has a potential role in modulating AhR pathways due to its binding affinity with a Kd of 50.0 nM. The compound demonstrates intrinsic clearance and microsomal stability in liver microsomes and hepatocytes of both mouse and human cells, indicating good stability and clearance characteristics across species. In a DMD disease mouse model myoblasts, it upregulates utrophin mRNA by 1.7-fold at 3 µM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and protein. Through this action, Ezutromid increases muscle function in dystrophin-deficient MDX mice, a mouse model of muscular dystrophy.
靶点活性	Small utrophin:0.4 μM
别名	依珠曲米, VOX-C1100, SMT C1100, BMN 195

化学信息

分子量	337.39
分子式	C₁₉H₁₅NO₃S
CAS No.	945531-77-1
Smiles	S(CC)(=O)(=O)C=1C=C2N=C(OC2=CC1)C3=CC4=C(C=C3)C=CC=C4
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 12 mg/mL (35.57 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9639 mL	14.8196 mL	29.6393 mL	148.1964 mL
5 mM	0.5928 mL	2.9639 mL	5.9279 mL	29.6393 mL
10 mM	0.2964 mL	1.4820 mL	2.9639 mL	14.8196 mL
20 mM	0.1482 mL	0.7410 mL	1.4820 mL	7.4098 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。