Metyrosine

Name: Metyrosine
Brand: TargetMol
SKU: T22368
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.72%

货号 T22368Cas号 672-87-7

别名 甲酪氨酸, α-Methyltyrosine

Metyrosine (α-Methyltyrosine) 是一种选择性酪氨酸羟化酶抑制剂，可显著抑制高 COX-2 活性和有效控制血压，具有抗炎和抗溃疡作用。

Metyrosine

一键复制产品信息

很棒

纯度: 99.72%

货号 T22368 别名 甲酪氨酸, α-MethyltyrosineCas号 672-87-7

Metyrosine (α-Methyltyrosine) 是一种选择性酪氨酸羟化酶抑制剂，可显著抑制高 COX-2 活性和有效控制血压，具有抗炎和抗溃疡作用。

规格	价格	库存	数量
100 mg	¥ 129	现货

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纯度: 99.72%

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COA HNMR LCMS 产品操作手册

产品介绍

Metyrosine AI Summary

Metyrosine exhibits a range of multi-target bioactivities. It shows potent inhibitory activity against numerous targets, including IMPase, Bloom's syndrome helicase (BLM), histone lysine methyltransferase G9a, human Flap endonuclease 1 (FEN1), Polymerase Iota, Marburg Virus entry, D2 Dopamine Receptor, Ebola Virus entry, and Schwann cell PMP22 intronic element. Additionally, it demonstrates significant antiviral activity against several viruses, notably inhibiting SARS-CoV-2-induced cytotoxicity in various cell lines and showing inhibitory effects against the SARS-CoV-2 3CL-Pro protease. The compound also impacts liver function, as indicated by increased activities of liver enzymes such as alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT). Despite these effects, the compound is assessed to have a low risk for drug-induced liver injury in humans. Further, Metyrosine exhibits significant inhibition of sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at an equimolar concentration of 10 uM. It shows minimal inhibition of human HDAC6 in enzymatic assays with custom peptide substrates and lacks notable binding affinity or inhibition towards other tested receptors/enzymes. The synthesis of these results highlights Metyrosine's potential as a multi-target therapeutic agent, with notable antiviral properties and specific biochemical activities that warrant further investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
别名	甲酪氨酸, α-Methyltyrosine

化学信息

分子量	195.22
分子式	C₁₀H₁₃NO₃
CAS No.	672-87-7
Smiles	C[C@](N)(Cc1ccc(O)cc1)C(O)=O
密度	1.283g/cm3

储存&溶解度

存储	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: < 1 mg/mL (insoluble) DMSO: < 1 mg/mL (insoluble or slightly soluble)