SAH-SOS1A

Name: SAH-SOS1A
Brand: TargetMol
SKU: TP2116
Rating: 4.5 (1 reviews)

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货号 TP2116Cas号 1652561-87-9

KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

SAH-SOS1A

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货号 TP2116Cas号 1652561-87-9

规格	价格	库存	数量
5 mg	¥ 13,473	待询

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产品介绍

生物活性

产品描述	KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.
靶点活性	KRas (G12D):109 nM (EC50), KRas (G12C):140 nM (EC50), KRas (G12V):154 nM (EC50), KRas (G12S):155 nM (EC50), KRas (Q61H):175 nM (EC50), KRas (WT):106 nM (EC50)

化学信息

分子量	2187.53
分子式	C₁₀₀H₁₅₉N₂₇O₂₈
CAS No.	1652561-87-9
Smiles	[C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=CC=C2)C(NCC(N[C@H](C(N[C@]3(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(N)=O)C(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CC(C)C)=O)(C)CCCC=CCCC3)[H])=O)[C@H](CC)C)=O)=O)=O)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O
密度	1.42 g/cm3 (Predicted)
Sequence	Arg-Arg-Phe-Phe-Gly-Ile-{Aaa}-Leu-Thr-Asn-{Aaa}-Leu-Lys-Thr-Glu-Glu-Gly-Asn (Covalent bridge:Aaa7-Aaa11)
Sequence Short	RRFFGI{Aaa}LTN{Aaa}LKTEEGN (Covalent bridge:Aaa7-Aaa11)

储存&溶解度

存储	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: 1 mg/mL (0.46 mM), Sonication is recommended.