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Bromhexine hydrochloride

Name: Bromhexine hydrochloride
Brand: TargetMol
SKU: T0828
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.98%

货号 T0828Cas号 611-75-6

别名 盐酸溴己新, Bromhexine HCl, Bisolvon, Auxit

Bromhexine hydrochloride (Bisolvon) 是TMPRSS2蛋白酶的一种特异性有效抑制剂，IC50为 0.75 μM。它可预防和控制SARS-CoV-2感染。它是一种粘液溶解剂，用于治疗与粘稠或过多粘液相关的呼吸系统疾病。

Bromhexine hydrochloride

一键复制产品信息

很棒

纯度: 99.98%

货号 T0828 别名 盐酸溴己新, Bromhexine HCl, Bisolvon, AuxitCas号 611-75-6

规格	价格	库存
1 g	¥ 198	现货
5 g	¥ 237	待询
1 mL x 10 mM (in DMSO)	¥ 237	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.98%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Bromhexine hydrochloride AI Summary

Bromhexine hydrochloride exhibits a wide range of bioactivities across various assays related to cellular functions, enzyme inhibition, and antiviral properties. It shows potency in assays such as modulators of Lamin A splicing, inhibitors of ROR gamma transcriptional activity, activators and inhibitors of Cytochrome P450 3A4, compounds blocking the interaction between CBF-beta and RUNX1 for the treatment of acute myeloid leukemia, and inhibitors of the malarial parasite plastid. Additionally, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in both absence and presence of CPT. It also demonstrates the ability to inhibit the binding or entry into cells for Lassa Virus, Marburg Virus, and Ebola Virus. Specifically, it inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 95.98% and in OATP1B1-transfected CHO cells by 103.11% at a concentration of 10 µM. Despite its broad bioactivity, Bromhexine hydrochloride shows minimal activity in inhibiting cell viability of SARS-CoV-2 (strain BavPat1) infected Vero E6 cells, with a very low inhibition index of 0.00411. However, it exhibits modest antiviral activity against SARS-CoV-2, with an inhibition rate of -38.2% in Caco-2 cells at 10 µM after 48 hours. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease by 13.35% at a concentration of 20 µM, as determined by a FRET assay using a peptide substrate. Lastly, Bromhexine hydrochloride inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells at a 10 µM concentration after 48 hours exposure, with an inhibition rate of 0.29%, as determined by high content imaging..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
别名	盐酸溴己新, Bromhexine HCl, Bisolvon, Auxit

化学信息

分子量	412.59
分子式	C₁₄H₂₁Br₂ClN₂
CAS No.	611-75-6
Smiles	Cl.CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 5.63 mg/mL (13.65 mM), Sonication is recommended.

Ethanol: 5 mg/mL (12.12 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4237 mL	12.1186 mL	24.2371 mL	121.1857 mL
5 mM	0.4847 mL	2.4237 mL	4.8474 mL	24.2371 mL
10 mM	0.2424 mL	1.2119 mL	2.4237 mL	12.1186 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

TMPRSS2 suppressant SARS-CoV SARSCoV SARS coronavirus respiratory mucolytic Inhibitor inhibit Human immunodeficiency virus HIVProtease HIV Protease HIV cough conditions Bromhexine hydrochloride Bromhexine Autophagy

Bromhexine hydrochloride

Bromhexine hydrochloride