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Phosphonoacetic acid

Name: Phosphonoacetic acid
Brand: TargetMol
SKU: T4729
Price: 163 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 磷酰基乙酸

货号 T4729Cas号 4408-78-0 一键复制产品信息纯度: 99.74%

很棒

Phosphonoacetic acid 是内源性代谢产物的一种。

Phosphonoacetic acid

一键复制产品信息

很棒

纯度: 99.74%

货号 T4729Cas号 4408-78-0

别名 磷酰基乙酸

Phosphonoacetic acid 是内源性代谢产物的一种。

规格	价格	库存
5 mg	¥ 163	现货
10 mg	¥ 225	现货
25 mg	¥ 349	现货
50 mg	¥ 496	现货
1 mL x 10 mM (in DMSO)	¥ 185	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.74%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Phosphonoacetic acid AI Summary

Phosphonoacetic acid exhibits a broad spectrum of bioactivities with notable antiviral and antiplasmodial properties. It shows in vitro cytotoxicity with a CC50 of 3500000.0 nM in Vero cells and demonstrates antiviral activity against herpes simplex virus type 1 (HSV-1) with an ED50 of 240.0 μM and type 2 (HSV-2) with an ID50 of 240.0 μM. The therapeutic index against HSV-1 is calculated to be 29.0, indicating selectivity for anti-HSV-1 activity. In vivo studies reveal that intravaginal administration of Phosphonoacetic acid at 2% and 5% dosages enhances the survival rate of mice infected with HSV-2, achieving a 90.0% survival rate and average survival exceeding 13.0 days. Additionally, Phosphonoacetic acid shows a protective effect against systemic HSV-1 infection in mice with a PD50 of 0.67 mM/kg. The compound also demonstrates antiplasmodial activity against Plasmodium falciparum strains 3D7, GB4, and W2 with IC50 values of 10000.0 nM, 12589.25 nM, and 10000.0 nM, respectively. Beyond its antiviral and antiplasmodial activities, Phosphonoacetic acid modulates Lamin A splicing potently (0.9 nM to 398.1 nM), acts as an agonist of the Thyroid Stimulating Hormone Receptor (potency of 39.8 nM), and inhibits various enzymes including Tyrosyl-DNA Phosphodiesterase and Histone Lysine Methyltransferase G9a. Its SARS-CoV-2 antiviral activity is indicated by an IC50 of greater than 19952.62 nM in VERO-6 cells. Phosphonoacetic acid's diverse biological activities suggest its potential in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Phosphonoacetate, also known as fosfonet or phosphonacetic acid, belongs to the class of organic compounds known as organic phosphonic acids.Within the cell, phosphonoacetate is primarily located in the cytoplasm. Phosphonoacetate can be biosynthesized from phosphonic acid and acetic acid.
别名	磷酰基乙酸

化学信息

分子量	140.03
分子式	C₂H₅O₅P
CAS No.	4408-78-0
Smiles	OC(=O)CP(O)(O)=O
密度	1.858g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 250 mg/mL (1785.33 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.1413 mL	35.7066 mL	71.4133 mL	357.0663 mL
5 mM	1.4283 mL	7.1413 mL	14.2827 mL	71.4133 mL
10 mM	0.7141 mL	3.5707 mL	7.1413 mL	35.7066 mL
20 mM	0.3571 mL	1.7853 mL	3.5707 mL	17.8533 mL
50 mM	0.1428 mL	0.7141 mL	1.4283 mL	7.1413 mL
100 mM	0.0714 mL	0.3571 mL	0.7141 mL	3.5707 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Phosphonoacetic acid Orthopoxvirus Inhibitor inhibit Human Endogenous Metabolite EndogenousMetabolite Endogenous Metabolite

Phosphonoacetic acid

Phosphonoacetic acid