Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.
产品描述 | MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability. |
体内活性 | MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the T max , C max , AUC and F% are 1?(h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively[1].MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals[1].MPC-0767 is well tolerated when administered at 252?mg/kg po (equivalent to 200?mg/kg dose of?MPC-3100)[1]. |
分子量 | 734.64 |
分子式 | C26H36BrN7O9S2 |
CAS No. | 1310540-32-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MPC-0767 1310540-32-9 MPC0767 MPC 0767 Inhibitor inhibitor inhibit