store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pomhex 是一种具有抗癌活性的细胞渗透性强效烯醇化酶抑制剂,可用于癌症致死率的研究。Pomhex是一种外消旋混合物,是一种强效且具有选择性的ENO2抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,470 | 现货 | ||
5 mg | ¥ 3,690 | 现货 | ||
10 mg | ¥ 5,330 | 现货 | ||
25 mg | ¥ 8,280 | 现货 | ||
50 mg | ¥ 11,170 | 现货 | ||
100 mg | ¥ 14,800 | 现货 |
产品描述 | Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycolytic process, and shows anticancer activity at low concentrations in an ENO1-deficient tumor model.Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is a potent and selective ENO2 inhibitor. |
体外活性 | POMHEX (78 nM, 8h) exhibits minimal impact on ENO1-WT glioma cells but significantly affects cells with ENO1 deletion[1]. POMHEX (0-720 nM) selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1-deleted glioma cells[1]. |
体内活性 |
When administered intravenously or intraperitoneally at a dosage of 10 mg/kg (body weight) per day, POMHEX is well-tolerated without inducing hemolytic anemia. However, intravenous injection of POMHEX at 35 mg/kg causes lethargy and necessitates euthanasia by veterinarians[1]. POMHEX rapidly hydrolyzes to Hemi POMHEX in mouse plasma ex vivo, with a half-life of approximately 30 seconds, and in human blood ex vivo, the half-life is around 9 minutes[1]. |
分子量 | 423.4 |
分子式 | C17H30NO9P |
CAS No. | 2004714-34-3 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (118.09 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3618 mL | 11.8092 mL | 23.6183 mL | 59.0458 mL |
5 mM | 0.4724 mL | 2.3618 mL | 4.7237 mL | 11.8092 mL | |
10 mM | 0.2362 mL | 1.1809 mL | 2.3618 mL | 5.9046 mL | |
20 mM | 0.1181 mL | 0.5905 mL | 1.1809 mL | 2.9523 mL | |
50 mM | 0.0472 mL | 0.2362 mL | 0.4724 mL | 1.1809 mL | |
100 mM | 0.0236 mL | 0.1181 mL | 0.2362 mL | 0.5905 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
POMHEX 2004714-34-3 Metabolism Glucokinase Inhibitor inhibitor inhibit