Name: SCH 42495 racemate
Brand: TargetMol
SKU: T12866
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述	SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.
体外活性	in vitro,SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF with IC50 of 8.3 and 10.0 nM, respectively[1].
体内活性	Significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days caused by SCH 42495 (30 mg/kg; oral gavage; twice daily). Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2]. SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1].
别名	SCH 42495 (racemate)

化学信息

分子量	411.58
分子式	C₂₀H₂₉NO₄S₂
CAS No.	145841-10-7
Smiles	C(CC1=C(C)C=CC=C1)(C(N[C@H](C(OCC)=O)CCSC)=O)CSC(C)=O
密度	1.158 g/cm3 (Predicted)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

SCH 42495 racemate