SCH 42495 racemate

Name: SCH 42495 racemate
Brand: TargetMol
SKU: T12866
Rating: 4.5 (1 reviews)

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产品编号 T12866Cas号 145841-10-7

别名 SCH 42495 (racemate)

SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.

SCH 42495 racemate

还可以

产品编号 T12866 别名 SCH 42495 (racemate)Cas号 145841-10-7

SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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SCH 42495 racemate 相关产品

产品介绍

生物活性

产品描述	SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.
体外活性	in vitro,SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF with IC50 of 8.3 and 10.0 nM, respectively[1].
体内活性	Significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days caused by SCH 42495 (30 mg/kg; oral gavage; twice daily). Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2]. SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1].
别名	SCH 42495 (racemate)