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顶部相关产品产品介绍化学信息储存和溶解信息计算器

α-Lipoic Acid

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纯度: 99.83%

货号 T0200Cas号 1077-28-7

别名 硫辛酸, α-硫辛酸, Thioctic acid, DL-α-Lipoic acid, 62-46-4, (±)-α-Lipoic acid, (±)-Lipoic acid

α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子，是一种抗氧化剂，可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。

α-Lipoic Acid
其他形式的 “α-Lipoic Acid”:
(S)-Thioctic acid
α-Lipoic Acid sodium
Lipoic acid

α-Lipoic Acid

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Rating icon 很棒

纯度: 99.83%

货号 T0200 别名 硫辛酸, α-硫辛酸, Thioctic acid, DL-α-Lipoic acid, 62-46-4, (±)-α-Lipoic acid, (±)-Lipoic acidCas号 1077-28-7

α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子，是一种抗氧化剂，可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。

规格价格库存数量
100 mg
¥ 108
现货
1 mL x 10 mM (in DMSO)
¥ 120
现货
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纯度: 99.83%
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产品介绍

α-Lipoic Acid AI Summary
α-Lipoic Acid has exhibited a broad spectrum of bioactivity in various assays. It demonstrates significant inhibitory effects on Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU) with an IC50 of 3910.0 nM and shows potency against the Menin-MLL interaction in MLL-Related Leukemias, as well as several other targets including Lamin A splicing, Thyroid Hormone Receptor interactions, and the retinoid-related orphan receptor gamma signaling pathway. Additionally, it induces the Endoplasmic Reticulum Stress Response in Human Glioma cells. The compound also displays anticancer properties, showing antiproliferative activity against a range of human cancer cell lines (such as K562, Bel7402, SGC7901, and A549) and exhibits cytotoxicity against human liver cells (L02) and peripheral blood mononuclear cells (PBMC), albeit with limited potency reflected by IC50 values greater than 50,000.0 nM. α-Lipoic Acid has demonstrated antiviral activity against SARS-CoV-2, with moderate to weak inhibitory effects on virus-induced cytotoxicity in VERO-6 cells at a concentration of 10 uM (IC50 > 19952.62 nM). It also shows a 24.81% and 14.23% inhibition rate of SARS-CoV-2 3CL-Pro protease at 20 µM in FRET-type assays. Moreover, α-Lipoic Acid inhibits human HDAC6 with approximately 7.98% and 7.9% inhibition in enzymatic assays. It significantly inhibits wild-type Candida albicans Fructose-1,6-Bisphosphate Aldolase transfected in Escherichia coli BL21 (DE3) by 80.0% at 50 uM concentration, as determined by spectrophotometric analysis. This compound also shows neuroprotective effects against amyloid beta (1 to 42)-induced neurotoxicity in human SH-SY5Y cells, enhancing cell viability and reducing necrosis rates in an Alzheimer's disease model. In terms of degradation and desulfhydration, α-Lipoic Acid releases hydrogen sulfide (H2S) in phosphate buffer with a half-life of 1.968 hours at 40 uM in the presence of L-cysteine, reaching a maximum concentration of 28400.0 nM of H2S. While α-Lipoic Acid binds to various receptors and enzymes, its activity is generally low, with no significant inhibitory or agonistic effects, as reflected by AC50 values above 30,000.0 nM in the provided data..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
别名硫辛酸, α-硫辛酸, Thioctic acid, DL-α-Lipoic acid, 62-46-4, (±)-α-Lipoic acid, (±)-Lipoic acid
化学信息
分子量206.33
分子式C8H14O2S2
CAS No.1077-28-7
SmilesOC(=O)CCCCC1CCSS1
密度1.218g/cm3
颜色Yellow
物理性状Solid
储存&溶解度
存储keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 250 mg/mL (1211.65 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.69 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM4.8466 mL24.2330 mL48.4660 mL242.3302 mL
5 mM0.9693 mL4.8466 mL9.6932 mL48.4660 mL
10 mM0.4847 mL2.4233 mL4.8466 mL24.2330 mL
20 mM0.2423 mL1.2117 mL2.4233 mL12.1165 mL
50 mM0.0969 mL0.4847 mL0.9693 mL4.8466 mL
100 mM0.0485 mL0.2423 mL0.4847 mL2.4233 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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