N-Acetylprocainamide

Name: N-Acetylprocainamide
Brand: TargetMol
SKU: T0249
Price: 226 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.74%

货号 T0249Cas号 32795-44-1

别名 乙酰普卡胺, N-乙酰普鲁卡因胺, NAPA, Acecainide

N-Acetylprocainamide (NAPA) 是K+通道抑制剂，是第三代抗心律失常剂。

N-Acetylprocainamide

一键复制产品信息

很棒

纯度: 99.74%

货号 T0249 别名 乙酰普卡胺, N-乙酰普鲁卡因胺, NAPA, AcecainideCas号 32795-44-1

N-Acetylprocainamide (NAPA) 是K+通道抑制剂，是第三代抗心律失常剂。

规格	价格	库存
25 mg	¥ 226	现货
50 mg	¥ 328	现货
1 mL x 10 mM (in DMSO)	¥ 354	现货

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纯度: 99.68%

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产品介绍

N-Acetylprocainamide AI Summary

N-Acetylprocainamide has demonstrated diverse bioactivities impacting cardiac function, electrophysiology, viral inhibition, and enzyme activity. It effectively increases the functional refractory period of canine ventricular muscle in vitro and blocks sustained ventricular tachycardia in anesthetized dogs following intravenous administration. The compound modifies repolarization, action potential duration, and conduction parameters in canine Purkinje fibers and ventricular muscle fibers, indicating its modulation of cardiac electrophysiology. Additionally, it inhibits the IKr potassium channel with an IC50 of 100,000 nM and the uptake of specific compounds in human OCT1 and OCT2 transporters across various cell lines. In terms of pharmacokinetics, N-Acetylprocainamide has a moderate clearance rate (4.0 mL.min-1.kg-1), a high fraction unbound after intravenous administration (Fu = 0.9), and a relatively low volume of distribution (1.9 L.kg-1). It exhibits a half-life of 6.4 hours and a mean residence time of 7.9 hours, implying a prolonged duration of action. The compound also demonstrates inhibitory activity against several transport proteins (BSEP, MRP2, MRP3, MRP4), although with weak potency (IC50 > 133,000 nM). Importantly, N-Acetylprocainamide displays antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in VERO-6 cells and the SARS-CoV-2 3CL-Pro protease, albeit with moderate inhibition percentages at tested concentrations. It also inhibits human HDAC6 enzymatic activity, though inhibition levels vary depending on the substrate used..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
别名	乙酰普卡胺, N-乙酰普鲁卡因胺, NAPA, Acecainide

化学信息

分子量	277.36
分子式	C₁₅H₂₃N₃O₂
CAS No.	32795-44-1
Smiles	CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
密度	1.097g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 150 mg/mL (540.81 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.42 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6054 mL	18.0271 mL	36.0542 mL	180.2711 mL
5 mM	0.7211 mL	3.6054 mL	7.2108 mL	36.0542 mL
10 mM	0.3605 mL	1.8027 mL	3.6054 mL	18.0271 mL
20 mM	0.1803 mL	0.9014 mL	1.8027 mL	9.0136 mL
50 mM	0.0721 mL	0.3605 mL	0.7211 mL	3.6054 mL
100 mM	0.0361 mL	0.1803 mL	0.3605 mL	1.8027 mL