Powder: -20°C for 3 years | In solvent: -80°C for 1 year
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是色氨酸羟化酶抑制剂和5-HT 合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。
产品描述 | pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability. |
体内活性 | In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or i.p. PCPA methyl ester hydrochloride(250, 500 mg/kg), respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% and 50%[4]. |
别名 | 4-氯-DL-苯基丙氨酸甲酯盐酸盐, 4-Chloro-DL-phenylalanine methyl ester hydrochloride |
分子量 | 250.12 |
分子式 | C10H13Cl2NO2 |
CAS No. | 14173-40-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 45 mg/mL (179.91 mM), ultrasonic and warming and heat to 60°C
DMSO: 245 mg/mL (979.53 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 3.9981 mL | 19.9904 mL | 39.9808 mL | 99.952 mL |
5 mM | 0.7996 mL | 3.9981 mL | 7.9962 mL | 19.9904 mL | |
10 mM | 0.3998 mL | 1.999 mL | 3.9981 mL | 9.9952 mL | |
20 mM | 0.1999 mL | 0.9995 mL | 1.999 mL | 4.9976 mL | |
50 mM | 0.08 mL | 0.3998 mL | 0.7996 mL | 1.999 mL | |
100 mM | 0.04 mL | 0.1999 mL | 0.3998 mL | 0.9995 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
pCPA methyl ester hydrochloride 14173-40-1 GPCR/G Protein Metabolism Neuroscience 5-HT Receptor Hydroxylase 5-HT Inhibitor PCPA methyl ester insomnia pCPA methyl ester Hydrochloride reversible 5-hydroxytryptamine Receptor BBB 4-氯-DL-苯基丙氨酸甲酯盐酸盐 Serotonin Receptor 4-Chloro-DL-phenylalanine methyl ester hydrochloride inhibit Tryptophan Hydroxylase inhibitor