Arecoline hydrobromide

Name: Arecoline hydrobromide
Brand: TargetMol
SKU: T2198
Price: 120 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.52%

货号 T2198Cas号 300-08-3

别名 氢溴酸槟榔碱, Arecoline HBr, Arecoline bromide

Arecoline hydrobromide (Arecoline HBr) 是从槟榔中得到的一种生物碱，具有刺激、警觉、抗焦虑和抗寄生虫作用。它是烟碱和毒蕈碱乙酰胆碱受体的部分激动剂，可诱导氧化应激。

Arecoline hydrobromide

一键复制产品信息

很棒

纯度: 99.52%

货号 T2198 别名 氢溴酸槟榔碱, Arecoline HBr, Arecoline bromideCas号 300-08-3

规格	价格	库存	数量
50 mg	¥ 150	现货
1 mL x 10 mM (in DMSO)	¥ 120	现货

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纯度: 99.52%

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产品介绍

Arecoline hydrobromide AI Summary

Arecoline hydrobromide is a versatile bioactive molecule exhibiting multiple pharmacological activities. It acts as an agonist of the endothelin A receptor, causing a significant vascular endothelium-dependent relaxation at a concentration of 10E-5 M/L with a relaxation effect of over 50.0%. Additionally, it shows agonism toward the Muscarinic acetylcholine receptor M3, enhancing the contraction rate of isolated guinea pig ileum by more than 50.0%. Although it shows inhibitory activity against HIV1 RT with an IC50 value greater than 200.0 μg/mL, its potential as an antiviral agent remains uncertain. Further, Arecoline hydrobromide inhibits the proliferation of Plasmodium falciparum and acts as a potent inhibitor of Bloom's syndrome helicase (BLM) and Histone Lysine Methyltransferase G9a. It also inhibits HP1-beta Chromodomain interactions with methylated histone tails and induces DNA re-replication in SW480 colon adenocarcinoma cells. The compound activates the transient receptor potential cation channel C4, although it does not significantly activate the transient receptor potential channel N1. It also shows inhibitory activity in the Nrf2 screen and has an agonistic effect on the transient receptor potential channel ML3. Additionally, Arecoline hydrobromide inhibits electric eel AChE by 16.92% and horse BChE by 0.29% at 2 mg/mL using Ellman's method. It demonstrates high inhibitory activity in sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM, with inhibition percentages of 103.72% and 112.58%, respectively. In antiviral assays, Arecoline hydrobromide shows promising activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 uM after 48 hours, with inhibition rates of -3.17% and 0.68%, respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease by 21.03% at a concentration of 20 µM, as detected through a FRET response from a peptide substrate. Overall, Arecoline hydrobromide demonstrates a broad spectrum of bioactivity including antiviral, anticancer, and enzyme inhibitory properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.
别名	氢溴酸槟榔碱, Arecoline HBr, Arecoline bromide

化学信息

分子量	236.11
分子式	C₈H₁₃NO₂·HBr
CAS No.	300-08-3
Smiles	Br.COC(=O)C1=CCCN(C)C1
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (211.77 mM), Sonication is recommended.

H2O: 100 mg/mL (423.53 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.47 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.2353 mL	21.1766 mL	42.3531 mL	211.7657 mL
5 mM	0.8471 mL	4.2353 mL	8.4706 mL	42.3531 mL
10 mM	0.4235 mL	2.1177 mL	4.2353 mL	21.1766 mL
20 mM	0.2118 mL	1.0588 mL	2.1177 mL	10.5883 mL
50 mM	0.0847 mL	0.4235 mL	0.8471 mL	4.2353 mL
100 mM	0.0424 mL	0.2118 mL	0.4235 mL	2.1177 mL