Clofentezine

Name: Clofentezine
Brand: TargetMol
SKU: T3493
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.57%

货号 T3493Cas号 74115-24-5

别名 四螨嗪, Bisclofentazin, Apollo, Acaristop

Clofentezine (Apollo) 是生长抑制剂，对螨虫具有显著的致死作用。

Clofentezine

一键复制产品信息

很棒

纯度: 99.57%

货号 T3493 别名 四螨嗪, Bisclofentazin, Apollo, AcaristopCas号 74115-24-5

Clofentezine (Apollo) 是生长抑制剂，对螨虫具有显著的致死作用。

规格	价格	库存
50 mg	¥ 123	现货
100 mg	¥ 163	现货
1 mL x 10 mM (in DMSO)	¥ 179	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.57%

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产品介绍

Clofentezine AI Summary

Clofentezine exhibits multiple bioactivities across different biological systems. It shows varying rates of inhibition of P388 tumor cell growth, peaking at 14.6% inhibition at 10E-7 mol/L, though it only achieves up to 12.6% inhibition at 10E-8 mol/L. In contrast, when tested on A549 tumor cells at similar concentrations, it does not yield significant inhibitory effects. The compound has been tested using both MTT and SRB methods, revealing inconsistent antiproliferative activities depending on the cell line and assay used. In addition to its tumor cell assays, Clofentezine demonstrates antagonist activity on thyroid hormone receptor beta signaling, agonist activity on the antioxidant response element (ARE) signaling pathway, and activation of both rat and human pregnane X receptor (PXR) signaling pathways, with potencies ranging from 7695.9 nM to 11220.2 nM. Clofentezine also displays notable insecticidal and acaricidal properties. It is effective against Tetranychus urticae FPY 14 and Tetranychus urticae GSS (two-spotted spider mites) with LC50 values of 68.52 mgAi/L and 14.32 mgAi/L respectively, and exhibits an insecticidal resistant ratio of 4.78 for Tetranychus urticae FPY 14 compared to GSS. Similarly, it is toxic to worker Bombus terrestris (bumblebees) when administered through pollen and sugar water, significantly affecting both reproduction and mortality rates over an 11-week period. Additionally, it shows strong insecticidal action against Panonychus ulmi, affecting eggs and larvae with low LC50 values. With these diverse bioactivities, Clofentezine represents a multifaceted agent in both biomedical research and agricultural pest management..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Clofentezine (Apollo) is an active substance of plant protection product used as the pesticide, acaricide.
别名	四螨嗪, Bisclofentazin, Apollo, Acaristop

化学信息

分子量	303.15
分子式	C₁₄H₈Cl₂N₄
CAS No.	74115-24-5
Smiles	Clc1ccccc1-c1nnc(nn1)-c1ccccc1Cl
密度	1.398g/cm3
颜色	Purple
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 8.33 mg/mL (27.48 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.3 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2987 mL	16.4935 mL	32.9870 mL	164.9349 mL
5 mM	0.6597 mL	3.2987 mL	6.5974 mL	32.9870 mL
10 mM	0.3299 mL	1.6493 mL	3.2987 mL	16.4935 mL
20 mM	0.1649 mL	0.8247 mL	1.6493 mL	8.2467 mL