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Felbinac

Name: Felbinac
Brand: TargetMol
SKU: T0888
Price: 331 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.47%

货号 T0888Cas号 5728-52-9

别名 Dapson, 4-联苯乙酸, 4-Biphenylacetic acid

Felbinac (Dapson) 是非甾体抗炎药，可用于肌肉炎症和关节炎的研究。

Felbinac

一键复制产品信息

很棒

纯度: 99.47%

货号 T0888 别名 Dapson, 4-联苯乙酸, 4-Biphenylacetic acidCas号 5728-52-9

Felbinac (Dapson) 是非甾体抗炎药，可用于肌肉炎症和关节炎的研究。

规格	价格	库存
500 mg	¥ 331	现货
1 g	¥ 415	现货
1 mL x 10 mM (in DMSO)	¥ 415	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.47%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Felbinac AI Summary

Felbinac exhibits a rapid absorption profile in rats, achieving maximum plasma concentration (Cmax) of 32508.83 nM within 0.5 hours (Tmax = 0.5 hr) and a mean residence time (MRT) of 6.6 hours. It demonstrates oral bioavailability in rats at 18.1% (F = 18.1%). The compound also shows notable bioactivities such as antioxidant and anti-inflammatory effects, as well as analgesic activity in animal models. For instance, it reduces myeloperoxidase, superoxide dismutase, catalase activities, and lipid peroxidation in rats' stomachs and alleviates carrageenan-induced paw edema in Sprague-Dawley rats. Moreover, Felbinac exhibits broad-spectrum bioactivities: - It acts as a modulator of Lamin A Splicing (potency: 2511.9 nM) and an agonist of the Thyroid Stimulating Hormone Receptor (potency: 5011.9 nM). - It activates intracellular cAMP concentrations in Parental HEK 293 cells by targeting the Thyroid Stimulating Hormone Receptor (potency: 5011.9 nM). - It demonstrates dual cytoprotective action in a Cell Model of Huntington (potency: 0.0501 nM) and inhibitory activity against Human alpha-Glucosidase (potency: 12589.3 nM). - It shows activity against Ebola Virus entry in screening assays with AC50 values ranging from 25.12 uM to 44668.4 nM. - It inhibits firefly luciferase and TDP-43 with potencies of 30131.3 nM and 35481.3 nM, respectively. - It acts as a cyclooxygenase COX-1 enzyme inhibitor (IC50: 894.0 nM) and inhibits human MRP4 activity in uptake assays (IC50: 8200.0 nM). Regarding antiviral activity, Felbinac shows limited effect against SARS-CoV-2 in multiple assays, including a low inhibition index (0.2263) in Vero E6 cells and an inhibition rate of 4.64% in Caco-2 cells. The compound exhibits an IC50 value greater than 20000.0 nM against SARS-CoV-2 in VERO-6 cells but shows inhibitory effects against the 3CL-Pro protease with an inhibition rate of 8.275% at 20 µM. Finally, Felbinac exhibits minor inhibitory effects on human HDAC6 enzyme activity, with 10.58% inhibition using a commercial peptide substrate, but lesser inhibition in custom peptide assays. Its binding affinity and receptor interactions suggest broad, albeit generally weak, bioactivities that require further exploration to fully characterize its therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Felbinac (Dapson), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs) of the arylpropionic acid class, which is used to treat muscle arthritis and inflammation.
靶点活性	COX-2:976 nM, COX-1:865.68 nM
别名	Dapson, 4-联苯乙酸, 4-Biphenylacetic acid

化学信息

分子量	212.24
分子式	C₁₄H₁₂O₂
CAS No.	5728-52-9
Smiles	OC(=O)CC1=CC=C(C=C1)C1=CC=CC=C1
密度	1.165 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (141.35 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.42 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7116 mL	23.5582 mL	47.1165 mL	235.5824 mL
5 mM	0.9423 mL	4.7116 mL	9.4233 mL	47.1165 mL
10 mM	0.4712 mL	2.3558 mL	4.7116 mL	23.5582 mL
20 mM	0.2356 mL	1.1779 mL	2.3558 mL	11.7791 mL
50 mM	0.0942 mL	0.4712 mL	0.9423 mL	4.7116 mL
100 mM	0.0471 mL	0.2356 mL	0.4712 mL	2.3558 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit Felbinac COX

Felbinac

Felbinac

Felbinac 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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