BAY-474

Name: BAY-474
Brand: TargetMol
SKU: T7900
Price: 253 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.98%

货号 T7900Cas号 1033767-86-0

BAY-474 是酪氨酸蛋白激酶 c-MET 抑制剂，能够用于表观遗传学探针。

为众多的药物研发团队赋能，

让新药发现更简单！

BAY-474

一键复制产品信息

很棒

纯度: 98.98%

货号 T7900Cas号 1033767-86-0

BAY-474 是酪氨酸蛋白激酶 c-MET 抑制剂，能够用于表观遗传学探针。

规格	价格	库存
1 mg	¥ 253	现货
5 mg	¥ 517	现货
10 mg	¥ 889	现货
25 mg	¥ 1,720	现货
50 mg	¥ 2,470	现货
100 mg	¥ 3,420	现货
200 mg	¥ 4,610	现货
1 mL x 10 mM (in DMSO)	¥ 526	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.98%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

BAY-474 AI Summary

BAY-474 demonstrates selective bioactivity across various cellular contexts and assays. It significantly promotes cell viability in human fibroblast cells with a growth rate of 1.0 but has no effect on the growth rates of HEK293T and U2OS cell lines. In Hs746T cells, the compound shows a strong inhibitory effect on cell proliferation with an IC90 of 56.0 nM. It also exhibits a potent biochemical affinity for the MET protein, with an IC50 of less than 1.0 nM in the Homogeneous Time Resolved Fluorescence Assay and 2.9 nM for the phosphorylation of MET in NKM-45 cells. Additionally, the compound affects thermal stability or conformation of proteins in a domain-specific manner as indicated by varied Delta TM values. Interaction assays reveal selective binding to the RPS6KA3 enzyme (IC50 of 900.0 nM), PTGER4 (19.0% inhibition), and HTR3A (32.97% control activity). Overall, BAY-474 shows promising domain-specific interactions and selective cellular effects, particularly in enhancing fibroblast viability and inhibiting cell proliferation related to MET targeting in specific cell lines..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe

化学信息

分子量	289.33
分子式	C₁₇H₁₅N₅
CAS No.	1033767-86-0
Smiles	Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C)=C1C#N
密度	1.29 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 120 mg/mL (414.75 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.83 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4563 mL	17.2813 mL	34.5626 mL	172.8131 mL
5 mM	0.6913 mL	3.4563 mL	6.9125 mL	34.5626 mL
10 mM	0.3456 mL	1.7281 mL	3.4563 mL	17.2813 mL
20 mM	0.1728 mL	0.8641 mL	1.7281 mL	8.6407 mL
50 mM	0.0691 mL	0.3456 mL	0.6913 mL	3.4563 mL
100 mM	0.0346 mL	0.1728 mL	0.3456 mL	1.7281 mL