Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1]. |
体外活性 | Tubulin polymerization-IN-37 (compound 2f, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50% [1]. Tubulin polymerization-IN-37 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells [1]. Tubulin polymerization-IN-37 (5 μΜ) inhibits colchicine binding to tubulin by 80% [1]. Tubulin polymerization-IN-37 shows cytotoxicity against MCF-7 cells (IC 50 : 0.21 μΜ) [1]. Cell Proliferation Assay [1] Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells. Concentration: 0-10 μΜ Incubation Time: 72 h Result: Inhibited cell proliferation to 28.1%, 8.6%, 7.3%, 13.8% at 1 μΜ, respectively. IC 50 s: 0.12, 0.07, 0.08, 0.07 μΜ, respectively. Cell Cycle Analysis [1] Cell Line: VL51 and MINO cells Concentration: 50 and 500 nM Incubation Time: 24, 48 and 72 h Result: Arrested cell in G2/M phase. |
分子量 | 340.37 |
分子式 | C19H20N2O4 |
CAS No. | 2011784-92-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tubulin polymerization-IN-37 2011784-92-0 Inhibitor inhibitor inhibit