Fenclonine

Name: Fenclonine
Brand: TargetMol
SKU: T1447
Price: 158 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.96%

货号 T1447Cas号 7424-00-2

别名 芬克洛宁, PCPA, Fenchlonine, DL-4-Chlorophenylalanine, CP-10188, 4-Chloro-DL-phenylalanine

Fenclonine (CP-10188) 是一种有效的色氨酸羟化酶(Trp)的不可逆抑制剂。其中色氨酸羟化酶是 5-羟色胺生物合成的限速酶。

Fenclonine

一键复制产品信息

很棒

纯度: 99.96%

货号 T1447 别名 芬克洛宁, PCPA, Fenchlonine, DL-4-Chlorophenylalanine, CP-10188, 4-Chloro-DL-phenylalanineCas号 7424-00-2

Fenclonine (CP-10188) 是一种有效的色氨酸羟化酶(Trp)的不可逆抑制剂。其中色氨酸羟化酶是 5-羟色胺生物合成的限速酶。

规格	价格	库存
100 mg	¥ 158	现货
200 mg	¥ 216	现货
500 mg	¥ 333	现货
1 g	¥ 418	现货
5 g	¥ 993	现货
10 g	¥ 1,460	现货

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纯度: 99.90%

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COA HNMR LCMS 产品操作手册

产品介绍

Fenclonine AI Summary

Fenclonine exhibits a broad range of bioactivities across various biological assays. It notably inhibits multiple enzymes such as Endonuclease IV, Bloom's syndrome helicase (BLM), Histone Lysine Methyltransferase G9a, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and Human Flap endonuclease 1 (FEN1). Additionally, it affects the human hERG channel activity, modulates Human Peripheral Myelin Protein 22 expression/activity, and enhances Arylsulfatase A (ASA1). It also interacts with HP1-beta Chromodomain and shows antiviral properties by inhibiting binding or entry of Marburg Virus and blocking Ebola Virus entry. Potencies in these assays range from 4.0 nM to 100000.0 nM. Fenclonine demonstrates notable antiviral activity against SARS-CoV-2, as evidenced by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, showing inhibition rates of -0.58% and 0.09% respectively. Additionally, it exhibits a SARS-CoV-2 3CL-Pro protease inhibition percentage of 0.8074% at 20 µM, and an IC50 value for this antiviral activity is greater than 20000.0 nM. Furthermore, Fenclonine demonstrates inhibitory activity on human HDAC6 enzyme, showing 19.51% inhibition with a commercial peptide substrate and 6.14% with a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin.
别名	芬克洛宁, PCPA, Fenchlonine, DL-4-Chlorophenylalanine, CP-10188, 4-Chloro-DL-phenylalanine

化学信息

分子量	199.63
分子式	C₉H₁₀ClNO₂
CAS No.	7424-00-2
Smiles	NC(Cc1ccc(Cl)cc1)C(O)=O
密度	1.336 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 1 mg/mL (5.01 mM), Sonication is recommended.

DMSO: 33 mg/mL (165.31 mM), pH is adjusted to 3 with HCl. Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0093 mL	25.0463 mL	50.0927 mL	250.4634 mL
5 mM	1.0019 mL	5.0093 mL	10.0185 mL	50.0927 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.5009 mL	2.5046 mL	5.0093 mL	25.0463 mL
20 mM	0.2505 mL	1.2523 mL	2.5046 mL	12.5232 mL
50 mM	0.1002 mL	0.5009 mL	1.0019 mL	5.0093 mL
100 mM	0.0501 mL	0.2505 mL	0.5009 mL	2.5046 mL