5-Fluoroorotic acid

Name: 5-Fluoroorotic acid
Brand: TargetMol
SKU: T19833
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.7%

货号 T19833Cas号 703-95-7

别名 5-氟乳清酸

5-Fluoroorotic 是一种胸苷酸合成酶的抑制剂，是酵母分子遗传学中的一种选择性试剂。它具有与 5-fluorocytosine 相近的良好表达的抗念珠菌作用，以及适度的抗皮肤真菌作用。

5-Fluoroorotic acid

一键复制产品信息

很棒

纯度: 99.7%

货号 T19833 别名 5-氟乳清酸Cas号 703-95-7

规格	价格	库存
200 mg	¥ 123	现货
500 mg	¥ 247	现货
1 g	¥ 413	现货
1 mL x 10 mM (in DMSO)	¥ 728	现货

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纯度: >99.99%

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产品介绍

5-Fluoroorotic acid AI Summary

5-Fluoroorotic acid exhibits a range of bioactivities. It has been shown to inhibit Mycobacterium Tuberculosis with IC50 values from 4580.0 nM to 6618.0 nM and Janus kinase 2 mutant JAK2V617F with IC50 values between 4121.0 nM and 6871.0 nM. Additionally, it targets Thyroid Hormone Receptor, Bacillus subtilis Sfp phosphopantetheinyl transferase, Fructose-1,6-bisphosphate Aldolase, and Histone Lysine Methyltransferase G9a, with potency values from 19905.4 nM to 28183.8 nM. The compound has cytotoxic effects on Ba/F3 cells and induces genotoxicity in HEK293T cells expressing luciferase-tagged ELG1. It also inhibits Trypanosoma cruzi dihydroorotate dehydrogenase with a Ki value of 19280.0 nM. However, 5-Fluoroorotic acid shows no significant antibacterial or antifungal activity, with MIC values and CC50 greater than 10,000.0 nM, indicating no substantial biological effect against Staphylococcus aureus MRSA, Klebsiella pneumoniae MDR, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Cryptococcus neoformans, or Candida albicans. Additionally, it exhibited no cytotoxicity against HEK293 cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects.
别名	5-氟乳清酸

化学信息

分子量	174.09
分子式	C₅H₃FN₂O₄
CAS No.	703-95-7
Smiles	OC(=O)c1[nH]c(=O)[nH]c(=O)c1F
密度	1.6154 g/cm3 (Estimated)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (718.02 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (22.98 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7442 mL	28.7208 mL	57.4416 mL	287.2078 mL
5 mM	1.1488 mL	5.7442 mL	11.4883 mL	57.4416 mL
10 mM	0.5744 mL	2.8721 mL	5.7442 mL	28.7208 mL
20 mM	0.2872 mL	1.4360 mL	2.8721 mL	14.3604 mL
50 mM	0.1149 mL	0.5744 mL	1.1488 mL	5.7442 mL
100 mM	0.0574 mL	0.2872 mL	0.5744 mL	2.8721 mL