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Primidone

Name: Primidone
Brand: TargetMol
SKU: T0024
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 去氧苯比妥, 扑米酮, Primaclone, NCI-C56360, Mysoline

货号 T0024Cas号 125-33-7 一键复制产品信息纯度: 99.91%

很棒

Primidone (NCI-C56360) 是一种强效抗惊厥试剂。它是神经元性电压门控钠通道阻滞剂，在癫痫、原发性震颤和精神疾病的研究中具有价值。

Primidone

一键复制产品信息

很棒

纯度: 99.91%

货号 T0024Cas号 125-33-7

别名 去氧苯比妥, 扑米酮, Primaclone, NCI-C56360, Mysoline

Primidone (NCI-C56360) 是一种强效抗惊厥试剂。它是神经元性电压门控钠通道阻滞剂，在癫痫、原发性震颤和精神疾病的研究中具有价值。

规格	价格	库存
25 mg	¥ 148	现货
50 mg	¥ 198	现货
100 mg	¥ 328	现货
500 mg	¥ 783	待询
1 g	¥ 1,150	待询
1 mL x 10 mM (in DMSO)	¥ 166	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 99.91%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS 产品操作手册

产品介绍

Primidone AI Summary

Primidone exhibits a diverse range of bioactivities, including significant inhibitory effects against various enzymes and receptors, as well as notable anticonvulsant, sedative, and antiviral properties. In enzymatic assays, it demonstrates less than 5.0% inhibition of beta-lactamase and chymotrypsin at concentrations of 100 uM and 250 uM, respectively, but shows 13.0% inhibition of malate dehydrogenase (MDH) at 400 uM. It also exhibits broad-spectrum inhibition against targets such as Tyrosyl-DNA Phosphodiesterase, DNA Polymerase Beta, Histone Lysine Methyltransferase G9a, and Cytochrome p450-cyp1a2, among others. Additionally, Primidone shows anticonvulsant and sedative effects with a median effective dose (ED50) of 58.6 mg/kg in the subcutaneous metrazole test. It acts as an agonist at the Thyroid Stimulating Hormone Receptor and androgen receptor signaling pathways. Furthermore, the compound demonstrates high oral bioavailability in humans, with an F value of 92.0% and a logD value of 0.91, indicating favorable partitioning properties. In antiviral assays, Primidone inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 and Vero E6 cells, showing specific inhibition rates and hit scores that suggest moderate activity against the virus. It also displays inhibitory activity against the SARS-CoV-2 3CL-Pro protease. In terms of liver toxicity, Primidone shows no significant adverse effects on hepatic functions, with a severity class index for drug-induced liver injury of 0.0. It also inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1 CHO cells, suggesting potential implications in drug transport interactions. Lastly, the compound has been found to have antifungal and antibacterial activity against various pathogens, including Candida albicans, Cryptococcus neoformans, and multiple bacterial strains such as Acinetobacter baumannii and Staphylococcus aureus MRSA. Overall, Primidone presents a versatile pharmacological profile with potential therapeutic applications across several domains..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Primidone (NCI-C56360) is a potent anticonvulsant agent. It is a neuronal voltage-gated sodium channel blocker and has value in the study of epilepsy, essential tremor, and psychiatric disorders.
别名	去氧苯比妥, 扑米酮, Primaclone, NCI-C56360, Mysoline

化学信息

分子量	218.25
分子式	C₁₂H₁₄N₂O₂
CAS No.	125-33-7
Smiles	CCC1(C(=O)NCNC1=O)C1=CC=CC=C1
密度	1.138g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 70 mg/mL (320.73 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.16 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5819 mL	22.9095 mL	45.8190 mL	229.0951 mL
5 mM	0.9164 mL	4.5819 mL	9.1638 mL	45.8190 mL
10 mM	0.4582 mL	2.2910 mL	4.5819 mL	22.9095 mL
20 mM	0.2291 mL	1.1455 mL	2.2910 mL	11.4548 mL
50 mM	0.0916 mL	0.4582 mL	0.9164 mL	4.5819 mL
100 mM	0.0458 mL	0.2291 mL	0.4582 mL	2.2910 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

tremor SodiumChannel Sodium Channel Psychiatric Primidone NCI-C-56360 NCI-C 56360 nAChR Na+ channels Na channels Inhibitor inhibit GluR2 GABAReceptor GABAR GABA Receptor essential epilepsy disorder

Primidone

Primidone

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产品介绍

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体内实验配液计算器

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