规格

价格

库存

数量

100 mg

¥ 129

现货

500 mg

¥ 318

现货

1 g

¥ 446

现货

1 mL x 10 mM (in DMSO)

¥ 195

现货

生物活性

产品描述	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.
靶点活性	H1 Receptor:1.01 mM
体内活性	Pheniramine maleate与组胺H1受体结合,从而抑制磷脂酶A2和内皮衍生的松弛因子NO的产生。随后通过NO缺乏鸟苷酸环化酶活化导致环GMP（cGMP）水平降低,由此抑制平滑肌组织的收缩,并降低毛细血管通透性和组胺激活的过敏反应。
别名	马来酸非尼拉敏, Trimetose, Inhiston, Daneral

化学信息

分子量	356.42
分子式	C₁₆H₂₀N₂·C₄H₄O₄
CAS No.	132-20-7
Smiles	CN(C)CCC(c1ccccc1)c1ccccn1.C(=C\C(=O)O)\C(=O)O
密度	1.2233 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 65 mg/mL (182.37 mM), Sonication is recommended.

Ethanol: 66 mg/mL (185.17 mM), Sonication is recommended.

DMSO: 40 mg/mL (112.23 mM), Sonication is recommended.

溶液配制表

DMSO/H2O/Ethanol