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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Trazodone hydrochloride

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纯度: 99.52%

货号 T1619Cas号 25332-39-2

别名 盐酸曲唑酮, Trazodone HCl, KB-831, AF-1161

Trazodone hydrochloride (Trazodone HCl) 是5 羟色胺受体拮抗剂和重吸收抑制剂，用作抗抑郁药，可治疗失眠和焦虑。

Trazodone hydrochloride
其他形式的 “Trazodone hydrochloride”:
Trazodone-d6 hydrochloride
Trazodone-d8 hydrochloride
Trazodone

Trazodone hydrochloride

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Rating icon 很棒

纯度: 99.52%

货号 T1619 别名 盐酸曲唑酮, Trazodone HCl, KB-831, AF-1161Cas号 25332-39-2

Trazodone hydrochloride (Trazodone HCl) 是5 羟色胺受体拮抗剂和重吸收抑制剂，用作抗抑郁药，可治疗失眠和焦虑。

规格价格库存数量
25 mg
¥ 132
现货
50 mg
¥ 178
现货
100 mg
¥ 247
现货
500 mg
¥ 497
现货
1 g
¥ 712
现货
2 g
¥ 987
现货
1 mL x 10 mM (in DMSO)
¥ 272
现货
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纯度: 99.52%
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产品介绍

生物活性
产品描述
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety.
别名盐酸曲唑酮, Trazodone HCl, KB-831, AF-1161
化学信息
分子量408.33
分子式C19H23Cl2N5O
CAS No.25332-39-2
SmilesCl.Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
H2O: 8.2 mg/mL (20.08 mM), Sonication is recommended.
DMSO: 20 mg/mL (48.98 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.45 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
H2O/DMSO
1mg5mg10mg50mg
1 mM2.4490 mL12.2450 mL24.4900 mL122.4500 mL
5 mM0.4898 mL2.4490 mL4.8980 mL24.4900 mL
10 mM0.2449 mL1.2245 mL2.4490 mL12.2450 mL
20 mM0.1224 mL0.6122 mL1.2245 mL6.1225 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Trazodone hydrochloride exhibits significant bioactivity across multiple biological targets and pathogens. It shows antiplasmodial activity against Plasmodium falciparum W2 with an IC50 of 10,000 nM after 72 hours using the SYBR green assay. Additionally, it inhibits human Jumonji Domain Containing 2E (JMJD2E) with potencies between 22,387.2 nM and 28,183.8 nM, and HSD17B4 (hydroxysteroid dehydrogenase 4) with a potency of 25,118.9 nM. The compound also differentially inhibits the proliferation of Plasmodium falciparum lines W2, GB4, and 7G8, with potencies ranging between 7,943.3 nM and 11,220.2 nM. Furthermore, Trazodone hydrochloride inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 25,118.9 nM, and HPGD (15-Hydroxyprostaglandin Dehydrogenase) with potencies between 28,183.8 nM and 35,481.3 nM. It effectively blocks chronic active B-cell receptor signaling at 6,513.1 nM and induces DNA re-replication in MCF 10a normal breast cells at a potency of 4.6 nM. The compound also inhibits Secretory Acid Sphingomyelinase (S-ASM) with a potency of 19,952.6 nM and shows variable efficacy in blocking Ebola Virus entry, with potencies ranging from 4,456.8 nM to 35,481.3 nM. In membrane vesicle transport assays, Trazodone hydrochloride shows weak or no inhibitory activity against human BSEP, MRP3, and MRP4 with IC50 values greater than 133,000.0 nM. It binds to human biotinylated HLA-A2 with a dissociation constant (Kd) of 2,500.0 nM as determined by surface plasmon resonance assay. Against SARS-CoV-2, Trazodone hydrochloride demonstrates inhibition of cell viability in Vero E6 cells at an MOI of 0.002 after 72 hours with an inhibition index of 0.9436. It also inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 4.71% at 10 µM after 48 hours and inhibits the SARS-CoV-2 3CL-Pro protease by 11.27% at 20 µM. However, its activity against SARS-CoV-2 induced cytotoxicity in Vero-6 cells at 10 µM is minimal (-0.13%). Additionally, Trazodone hydrochloride displays antifungal activity against Candida albicans and Cryptococcus neoformans with inhibition percentages of 3.08% and -5.73%, respectively. Its antibacterial activity varies, showing inhibition percentages of 0.18% against Escherichia coli, 4.82% against Klebsiella pneumoniae, 14.2% against Pseudomonas aeruginosa, 9.41% against Acinetobacter baumannii, and 11.44% against Staphylococcus aureus MRSA..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

Trazodone hydrochlorideTrazodoneSert (Sodium-dependent)Serotonin ReceptorKB831KB 831InhibitorinhibitHistamineReceptorHistamine ReceptorH1 receptorAF1161AF 1161AdrenergicReceptorAdrenergic Receptor5-hydroxytryptamine Receptor5HTReceptor5-HT Receptor5HT Receptor5-HT
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