规格

价格

库存

数量

1 mg

¥ 273

现货

5 mg

¥ 708

现货

10 mg

¥ 1,120

现货

25 mg

¥ 1,780

现货

50 mg

¥ 2,630

现货

100 mg

¥ 3,530

现货

200 mg

¥ 4,890

现货

1 mL x 10 mM (in DMSO)

¥ 772

现货

生物活性

产品描述	RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).
靶点活性	Tankyrase 1:14.3 nM, Tankyrase 2:10.6 nM
体外活性	RK-287107 (0.03-10 μM; 16 hours) also downregulates β-catenin signaling in cultured cells. 287107 (0.03-10 μM; 16 hours) induces the accumulation of tankyrase and Axin1/2. RK-87107 (0.01-10 μM; 12 hours) displays an antiproliferative effect on colorectal cancer cells harboring short adenomatous polyposis coli mutations. The 50% growth inhibition (GI50) value of RK-287107 on COLO-320DM cells is 0.449 μM. RK- [1].
体内活性	In a mouse xenograft model, RK-287107 (100 and 300 mg/kg; i.p. administration; once per day; 5-days on/ 2-days off schedule for 2 weeks) inhibits tumor growth [1].

化学信息

分子量	416.46
分子式	C₂₂H₂₆F₂N₄O₂
CAS No.	2171386-10-8
Smiles	OCCN1CC2(CCN(CC2)c2nc3CCCCc3c(=O)[nH]2)c2c1cc(F)cc2F
密度	1.48 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 120 mg/mL (288.14 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.6 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4012 mL	12.0060 mL	24.0119 mL	120.0595 mL
5 mM	0.4802 mL	2.4012 mL	4.8024 mL	24.0119 mL
10 mM	0.2401 mL	1.2006 mL	2.4012 mL	12.0060 mL
20 mM	0.1201 mL	0.6003 mL	1.2006 mL	6.0030 mL
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4012 mL
100 mM	0.0240 mL	0.1201 mL	0.2401 mL	1.2006 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

RK-287107

RK-287107

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

RK-287107

RK-287107

RK-287107 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词