P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product Name	CAS No.	Purity
T70489	Enerisant HCl 盐酸Enerisant	1152749-07-9	98%
T70489	Enerisant HCl是一种新型强效选择性组胺H3受体拮抗剂，是P-gp的底物，由细胞色素P450（CYP）和转运蛋白介导。
T30161	EN3356 化合物EN3356	1429329-63-4	98%
T30161	EN3356 是一种可口服且具有选择性的类固醇 17-α- 羟化酶/C17,20 裂解酶（CYP17A1 或 CYP17）抑制剂，是一种非甾体类裂解酶选择性化合物，具有潜在的抗雄激素和抗肿瘤活性。
T7725	Albaconazole 阿巴康唑	187949-02-6	98%
T7725	Albaconazole是一种小分子真菌细胞色素P450家族成员51 （fungal CYP51A1）抑制剂。它可用于治疗真菌感染、皮肤和肌肉骨骼疾病，可用于研究外阴阴道念珠菌病、Chagas病和泌尿生殖系统疾病。
T5786	TETRAHYDROPIPERINE 四氢胡椒碱	23434-88-0	98%
T5786	Tetrahydropiperine 是胡椒碱的环己基类似物，也是第一种天然芳基戊酰胺，从Piper longum 分离得到。它对细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH；IC50=23 µM)具有抑制作用。
TN2144	Resveratroloside 白藜芦醇-4'-O-葡萄糖苷	38963-95-0	98%
TN2144	Resveratroloside 是α-glucosidase 的竞争性抑制剂，可以对血糖水平进行调节，对心脏具有保护作用。
T8182	Guanfu base A 关附甲素	1394-48-5	98%
T8182	Guan-fu base A 是一种生物碱，分离自 Aconitum coreanum，是非竞争性 CYP2D6抑制剂，对人肝微粒体 (HLM) 的 Ki 为 1.20 μM，对人重组体 (rCYP2D6) 的 Ki 为 0.37 μM。它也是 CYP2D 的有效竞争抑制剂。它还能抑制 HERG 通道电流。Guan-fu...
TN4800	Pisatin 化合物 TN4800	20186-22-5	98%
TN4800	Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.).
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate 化合物 TN3294	67667-71-4	98%
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TQ0109	Cephaeline dihydrochloride 盐酸吐根酚碱	5853-29-2	98%
TQ0109	(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
T10535	BI 653048 化合物 T10535	1198784-72-3	98%
T10535	BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
T16739	RG-12525 化合物 T16739	120128-20-3	98%
T16739	RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
TN4424	Lecanoric acid 化合物 TN4424	480-56-8	98%
TN4424	Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased d...
TN4277	Isocupressic acid 化合物 TN4277	1909-91-7	98%
TN4277	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
TMA2106	(-)-Sparteine 化合物 TMA2106	24915-04-6	98%
TMA2106	Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 ...
TN5278	Zederone 化合物 TN5278	7727-79-9	98%
TN5278	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate 化合物 TN3300	83182-58-5	98%
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
TMA0164	15-Hydroxydehydroabietic acid 化合物 TMA0164	54113-95-0	98%
TMA0164	15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
TN2147	Retrorsine 倒千里光碱	480-54-6	98%
TN2147	Retrorsine 特异性地抑制肝细胞增殖，并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。
T10891	CRTH2-IN-1 化合物 T10891	926661-54-3	98%
T10891	CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
TN1378	α-Viniferin α-葡萄素	62218-13-7	98%
TN1378	α-Viniferin 属于一类有机化合物，也称为2-芳基苯并呋喃类黄酮，是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性