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Ciprofibrate

Name: Ciprofibrate
Brand: TargetMol
SKU: T1264
Price: 204 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.63%

货号 T1264Cas号 52214-84-3

别名 环丙贝特, Win35833

Ciprofibrate (Win35833) 是一种有效的过氧化物酶体增殖物，可增加PPARα的磷酸化水平。它是一种可口服的降血脂剂，可研究原发性高脂血症。

Ciprofibrate

一键复制产品信息

很棒

纯度: 99.63%

货号 T1264 别名 环丙贝特, Win35833Cas号 52214-84-3

Ciprofibrate (Win35833) 是一种有效的过氧化物酶体增殖物，可增加PPARα的磷酸化水平。它是一种可口服的降血脂剂，可研究原发性高脂血症。

规格	价格	库存
50 mg	¥ 298	现货
100 mg	¥ 418	现货
500 mg	¥ 1,050	现货
1 mL x 10 mM (in DMSO)	¥ 204	现货

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COA LCMS HNMR 产品操作手册

产品介绍

Ciprofibrate AI Summary

Ciprofibrate exhibits a diverse range of bioactivities across multiple cellular and molecular assays. It demonstrates agonist activity at PPARalpha, particularly in human HepG2 cells with an EC50 of 900 nM and a fold change of 2.2 at 1.45 μg/mL, indicating potential in modulating PPARalpha signaling. In rat H4IIE cells, it shows an EC50 value of over 10,000 nM for gene induction via PPARalpha. Furthermore, it exhibits binding affinity towards rat recombinant L-FABP, achieving 85% activity at the low affinity site and 100% at the high affinity site via NMR. The compound also possesses antiproliferative effects against human PC3 cells, demonstrating a fold change (FC) value of 1.047 at 30 μM after 120 hours. Additionally, Ciprofibrate modulates multiple signals and pathways, including the Aryl hydrocarbon Receptor (AhR), Bloom's syndrome helicase, AmpC Beta-Lactamase, GCN5L2, and others, reflecting a broad spectrum of interaction. Ciprofibrate inhibits SARS-CoV-2 induced cytotoxicity in several cell lines, though with generally low potency, showing inhibitory values far above 20,000 nM, and demonstrates minimal inhibition of SARS-CoV-2 3CL-Pro protease at 20 μM. It also shows limited antiviral activity against SARS-CoV-2 in HRCE cells (hit score: 0.1099). Notably, Ciprofibrate displays inhibitory activity against human HDAC6 enzyme with modest percentages, suggesting potential as an HDAC6 inhibitor. It shows inhibitory effects on bile salt export pump (BSEP) in both rat and human models, reflecting its potential impact on bile acid transport. Additionally, it does not inhibit UGT1A10, BSEP, MRP3, or MRP4 significantly, as all IC50 values are greater than the upper threshold tested. Despite its multiple activities, Ciprofibrate has been flagged for moderate to severe hepatotoxicity according to Drug Induced Liver Injury (DILI) prediction systems and exhibits interactions with human recombinant enzymes UGT1A3 and UGT1A8 with activity levels around 84-86 pm/min/mg. Overall, Ciprofibrate demonstrates a varied bioactivity profile, with significant interactions in several biochemical and cellular contexts but often with relatively high effective concentrations or low potency..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ciprofibrate (Win35833) is a fibrate derivative with antilipidemic activity.
别名	环丙贝特, Win35833

化学信息

分子量	289.15
分子式	C₁₃H₁₄Cl₂O₃
CAS No.	52214-84-3
Smiles	CC(C)(OC1=CC=C(C=C1)C1CC1(Cl)Cl)C(O)=O
密度	1.37 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 54 mg/mL (186.75 mM), Sonication is recommended.

DMSO: 45 mg/mL (155.63 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.92 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.4584 mL	17.2921 mL	34.5841 mL	172.9206 mL
5 mM	0.6917 mL	3.4584 mL	6.9168 mL	34.5841 mL
10 mM	0.3458 mL	1.7292 mL	3.4584 mL	17.2921 mL
20 mM	0.1729 mL	0.8646 mL	1.7292 mL	8.6460 mL
50 mM	0.0692 mL	0.3458 mL	0.6917 mL	3.4584 mL
100 mM	0.0346 mL	0.1729 mL	0.3458 mL	1.7292 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Win-35833 Win 35833 proliferator PPARalpha PPAR Peroxisome proliferator-activated receptors peroxisome Inhibitor inhibit hypolipidaemic hyperlipidaemias Ciprofibrate

Ciprofibrate

Ciprofibrate

Ciprofibrate 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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