Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CRK12-IN-1 是一种有效的CRK12抑制剂。CRK12-IN-1具有杀虫活性, 对布氏锥虫 (T.b. brucei) 和刚果锥虫 (T. congolense) 具有抑制作用EC50分别为1.3和18 nM。CRK12-IN-1能迅速杀死病原细胞。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,350 | 现货 | ||
5 mg | ¥ 5,630 | 现货 | ||
10 mg | ¥ 7,790 | 现货 | ||
25 mg | ¥ 11,200 | 现货 | ||
50 mg | ¥ 13,800 | 现货 | ||
100 mg | ¥ 17,500 | 现货 | ||
500 mg | ¥ 34,800 | 现货 |
产品描述 | CRK12-IN-1 is a potent CRK12 inhibitor.CRK12-IN-1 has insecticidal activity, with inhibitory effects on Trypanosoma brucei (T.b. brucei) and Trypanosoma congolense (T. congolense) with EC50s of 1.3 and 18 nM, respectively.CRK12-IN-1 kills the pathogenic cells rapidly. |
靶点活性 | T. congolense:1.3 nM, T. vivax:18 nM |
体外活性 | CRK12-IN-1(compound 1) (10 mg/mL; 69 h) demonstrates exceptional potency against T.b. brucei, proving highly effective in animal models of T.b. brucei infection. Additionally, it serves as a potent inhibitor of T. congolensei, with EC50 values of 1.3 and 18 nM, respectively.[1] |
体内活性 |
CRK12-IN-1 (compound 1) (5 mg free base/kg, i.m. or 2.5 mg free base/kg, i.v.; 0.25-120 h) has a moderate clearance from the blood and a relatively short half-life (about1.8 h) in male ruminating Holstein-Friesian, and penetrate tissues beyond the vasculature.[1] CRK12-IN-1 (5 mg/kg; s.c.; twice 12 h apart for 4 days) can suppress parasitemia below the level of detection in T. congolense infected calves, but parasitemia quickly re-emerges following the cessation of treatment.[1] CRK12-IN-1 (10 mg free base/kg; s.c.; for 0.08-8 h) has 74% of bioavailability with a half-life of about 1 hour in female NMRI mice.[1] CRK12-IN-1 (50 or 10 mg/kg; s.c.; once daily for 4 days) can elicit sterile cure against T. congolense infected mice, also has the same effect but marginally more efficacious (30 or 3 mg/kg; s.c.; daily, for 4 days) in against T. vivax infected mice.[1] |
分子量 | 472.57 |
分子式 | C20H26F2N4O3S2 |
CAS No. | 1990479-14-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CRK12-IN-1 1990479-14-5 Microbiology/Virology Antibiotic Inhibitor inhibitor inhibit