Spiperone

Name: Spiperone
Brand: TargetMol
SKU: T0280
Price: 658 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.91%

货号 T0280Cas号 749-02-0

别名 螺哌隆, Spiropitan, Spiroperidol

Spiperone (Spiropitan) 是多巴胺 D2、血清素5-HT1A 和血清素5-HT2A 拮抗剂。它是广泛使用的药理学工具。它具有研究神经系统疾病的潜力。

Spiperone

一键复制产品信息

很棒

纯度: 99.91%

货号 T0280 别名 螺哌隆, Spiropitan, SpiroperidolCas号 749-02-0

Spiperone (Spiropitan) 是多巴胺 D2、血清素5-HT1A 和血清素5-HT2A 拮抗剂。它是广泛使用的药理学工具。它具有研究神经系统疾病的潜力。

规格	价格	库存
1 mg	¥ 142	现货
5 mg	¥ 287	现货
10 mg	¥ 407	现货
25 mg	¥ 658	现货
50 mg	待询	现货
1 mL x 10 mM (in DMSO)	¥ 387	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.91%

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COA HNMR LCMS 产品操作手册

产品介绍

Spiperone AI Summary

Spiperone exhibits significant binding affinities and bioactivities across various serotonin and dopamine receptors, as well as other targets. It shows high affinity for the rat 5-hydroxytryptamine 2 receptor (Ki = 1.0 nM) and the dopamine receptor D2 (Ki = 0.045 nM). Additionally, it has moderate to high binding affinity for several other serotonin receptors including 5-HT1A, 5-HT7, and 5-HT2A, with Ki values of 30.0 nM, 19.95 nM, and 1.8 nM, respectively. The compound also exhibits strong inhibitory activity against dopamine D3 and D4 receptors with Ki values of 0.25 nM and 0.33 nM, respectively, and demonstrates potential multi-target activity across dopaminergic and serotonergic systems. Furthermore, Spiperone shows high potency in displacing radioligands from dopamine D2 receptors (IC50 = 0.06 nM) and a significant selectivity towards these receptors compared to others. In terms of adrenergic receptors, it displays notable affinity for the Alpha-1A adrenergic receptor (Ki = 7.2 nM). The compound has demonstrated cardiotoxic effects, such as QTc prolongation in guinea pigs, and exhibits various bioactivities, including inhibition of sodium fluorescein uptake and displacement of [3H]BTX-B from sodium channels. It has also shown antiviral activity, inhibiting SARS-CoV-2 replication in vitro with IC50 values around 20400.0 nM. Overall, the diverse range of bioactivities associated with Spiperone suggests its potential therapeutic applications in neurological disorders, psychiatric conditions, and possibly antiviral treatments, while also highlighting the need for careful consideration of its cardiotoxicity and broad receptor interactions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
别名	螺哌隆, Spiropitan, Spiroperidol

化学信息

分子量	395.47
分子式	C₂₃H₂₆FN₃O₂
CAS No.	749-02-0
Smiles	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
密度	1.1714 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (63.22 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.11 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5286 mL	12.6432 mL	25.2864 mL	126.4318 mL
5 mM	0.5057 mL	2.5286 mL	5.0573 mL	25.2864 mL
10 mM	0.2529 mL	1.2643 mL	2.5286 mL	12.6432 mL
20 mM	0.1264 mL	0.6322 mL	1.2643 mL	6.3216 mL
50 mM	0.0506 mL	0.2529 mL	0.5057 mL	2.5286 mL