Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin inhibitor 17 (Compound 3b) 是微管蛋白聚合抑制剂(IC50 = 12.38 μM)。Tubulin inhibitor 17 显示出抗癌活性并且诱导细胞凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | Tubulin inhibitor 17 (Compound 3b) is an inhibitor of tubulin polymerization (IC50 = 12.38 µM). Tubulin inhibitor 17 exhibits anticancer activities as well as induces cell apoptosis[1]. |
体外活性 | Tubulin inhibitor 17 (Compound 3b) (0-10 μM, 0-72 h) shows antiproliferative activities against cancer cells and inhibits colony formation of HepG-2 cells [1]. Tubulin inhibitor 17 (0-2.5 μM) concentration dependently inhibits tubulin polymerization[1]. Tubulin inhibitor 17 (0-1 μM, 12 h) dose-dependently induces the collapse of the microtubule networks[1]. Tubulin inhibitor 17 (0-5 μM, 24 h) induces cell cycle arrest at G2/M phase as well as inhibits cell migration of HepG-2 cells [1]. Tubulin inhibitor 17 (0-5 μM, 48 h) induces apoptosis in HepG-2 cells [1]. Cell Proliferation Assay [1] Cell Line: B16-F10, HepG-2, Hela and MCF-7 Concentration: 0, 0.5, 2.5, 5.0, 7.5 and 10 μM Incubation Time: 48 h for IC 50 measurement, 0-72 h for cell viability Result: Demonstrated antiproliferative activities with IC 50 values of 0.563 ± 0.099, 0.261 ± 0.025, 2.047 ± 0.168 and 0.609 ± 0.062 μM against B16-F10, HepG-2, Hela and MCF-7 cells, respectively. Inhibited the cell viability in a concentration- and time-dependent manner. Cell Cycle Analysis [1] Cell Line: HepG-2 Concentration: 0.5, 1.0 and 5.0 μM Incubation Time: 24 h Result: Dose-dependent induction of cell cycle arrest in G2/M phase. Apoptosis Analysis [1] Cell Line: HepG-2 Concentration: 0.5, 1.0 and 5.0 μM Incubation Time: 48 h Result: The overall proportion of apoptotic cells was significantly increased compared to the control. |
分子量 | 264.32 |
分子式 | C17H16N2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tubulin inhibitor 17 Inhibitor inhibitor inhibit