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LY83583
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很棒纯度: 99.80%
货号 T21576Cas号 91300-60-6
别名 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedione
LY83583 是一种可溶性鸟苷酸环化酶竞争性抑制剂，IC50 为 2 µM。
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LY83583
一键复制产品信息 很棒纯度: 99.80%
货号 T21576 别名 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedioneCas号 91300-60-6
LY83583 是一种可溶性鸟苷酸环化酶竞争性抑制剂，IC50 为 2 µM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 315 | 现货 | |
| 5 mg | ¥ 747 | 现货 | |
| 10 mg | ¥ 1,180 | 现货 | |
| 25 mg | ¥ 2,380 | 现货 | |
| 50 mg | ¥ 3,870 | 现货 | |
| 100 mg | ¥ 5,370 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 723 | 现货 |
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产品介绍
LY83583 AI Summary
LY83583 exhibits a broad spectrum of inhibitory and regulatory activities across different biological systems. In the context of vascular biology, it shows inhibitory activity in the vasorelaxation process induced by acetylcholine on phenylephrine-precontracted rat aorta with intact endothelium, featuring an EC50 value of 335.0 nM and achieving 77.0% of maximal acetylcholine-induced vasorelaxation. In yeast assays, LY83583 inhibits the cytostatic effect of 50 nM rapamycin in Saccharomyces cerevisiae strain BY4742 with an EC50 value of 10400.0 nM and affects the expression of a variety of genes, indicating its regulatory roles in gene expression. Specifically, it increases the expressions of GUF1, FMP38, HMI1, YRR1, YDR514C, SUV3, PET111, MDL1, MRPS28, and MAM1, while decreasing the expressions of FET4, RIM11, HOS1, YDR222W, YKR75C, YJL051W, SGN1, and YMD8. Additionally, LY83583 inhibits yeast Guf1 with an IC50 value of 300000.0 nM. It also exhibits potency in a range of assays, including inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1), Tau Fibril Formation, ROR gamma transcriptional activity, Aldehyde Dehydrogenase, Bacillus subtilis Sfp phosphopantetheinyl transferase, IMPase, Histone Lysine Methyltransferase G9a, and the Menin-MLL Interaction. Furthermore, it shows activity against Glioma stress response, vitamin D receptor inhibition, and viral binding or entry inhibition for Lassa Virus, Marburg Virus, and Foot and Mouth Disease Virus. Notably, LY83583 also inhibits soluble guanylate cyclase with an IC50 value of 1000.0 nM. These diverse activities suggest that LY83583 has potential therapeutic implications across various biological pathways and disease models..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM. |
| 别名 | 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedione |
| 分子量 | 250.25 |
| 分子式 | C15H10N2O2 |
| CAS No. | 91300-60-6 |
| Smiles | O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12 |
| 密度 | 1.400 g/cm3 (Predicted) |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 2.51 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4 mM), Sonication is recommended. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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