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LY83583

Name: LY83583
Brand: TargetMol
SKU: T21576
Price: 315 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.80%

货号 T21576Cas号 91300-60-6

别名 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedione

LY83583 是一种可溶性鸟苷酸环化酶竞争性抑制剂，IC50 为 2 µM。

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LY83583

一键复制产品信息

很棒

纯度: 99.80%

货号 T21576 别名 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedioneCas号 91300-60-6

LY83583 是一种可溶性鸟苷酸环化酶竞争性抑制剂，IC50 为 2 µM。

规格	价格	库存
1 mg	¥ 315	现货
5 mg	¥ 747	现货
10 mg	¥ 1,180	现货
25 mg	¥ 2,380	现货
50 mg	¥ 3,870	现货
100 mg	¥ 5,370	现货
1 mL x 10 mM (in DMSO)	¥ 723	现货

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实验操作小课堂

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纯度: 99.80%

颜色: 红色

性状: Solid

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COA HNMR LCMS 产品操作手册

产品介绍

LY83583 AI Summary

LY83583 exhibits a broad spectrum of inhibitory and regulatory activities across different biological systems. In the context of vascular biology, it shows inhibitory activity in the vasorelaxation process induced by acetylcholine on phenylephrine-precontracted rat aorta with intact endothelium, featuring an EC50 value of 335.0 nM and achieving 77.0% of maximal acetylcholine-induced vasorelaxation. In yeast assays, LY83583 inhibits the cytostatic effect of 50 nM rapamycin in Saccharomyces cerevisiae strain BY4742 with an EC50 value of 10400.0 nM and affects the expression of a variety of genes, indicating its regulatory roles in gene expression. Specifically, it increases the expressions of GUF1, FMP38, HMI1, YRR1, YDR514C, SUV3, PET111, MDL1, MRPS28, and MAM1, while decreasing the expressions of FET4, RIM11, HOS1, YDR222W, YKR75C, YJL051W, SGN1, and YMD8. Additionally, LY83583 inhibits yeast Guf1 with an IC50 value of 300000.0 nM. It also exhibits potency in a range of assays, including inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1), Tau Fibril Formation, ROR gamma transcriptional activity, Aldehyde Dehydrogenase, Bacillus subtilis Sfp phosphopantetheinyl transferase, IMPase, Histone Lysine Methyltransferase G9a, and the Menin-MLL Interaction. Furthermore, it shows activity against Glioma stress response, vitamin D receptor inhibition, and viral binding or entry inhibition for Lassa Virus, Marburg Virus, and Foot and Mouth Disease Virus. Notably, LY83583 also inhibits soluble guanylate cyclase with an IC50 value of 1000.0 nM. These diverse activities suggest that LY83583 has potential therapeutic implications across various biological pathways and disease models..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
别名	6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedione

化学信息

分子量	250.25
分子式	C₁₅H₁₀N₂O₂
CAS No.	91300-60-6
Smiles	O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12
密度	1.400 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

DMSO: 2.51 mg/mL (10.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9960 mL	19.9800 mL	39.9600 mL	199.8002 mL
5 mM	0.7992 mL	3.9960 mL	7.9920 mL	39.9600 mL
10 mM	0.3996 mL	1.9980 mL	3.9960 mL	19.9800 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。