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Butamben

Name: Butamben
Brand: TargetMol
SKU: T0916
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.43%

货号 T0916Cas号 94-25-7

别名 Butyl 4-aminobenzoate, 4-氨基苯甲酸丁酯

Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂，用于治疗慢性疼痛。

Butamben

一键复制产品信息

很棒

纯度: 99.43%

货号 T0916 别名 Butyl 4-aminobenzoate, 4-氨基苯甲酸丁酯Cas号 94-25-7

Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂，用于治疗慢性疼痛。

规格	价格	库存	数量
10 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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产品介绍

Butamben AI Summary

Butamben inhibits the binding of Batrachotoxinin to high-affinity sites on voltage-dependent sodium channels, with inhibition rates of 7.0% at 10 µM and 36.8% at 100 µM. It displays a binding affinity to beta cyclodextrin with a log Ks value of 3.19. This compound modulates various biological pathways, including Lamin A splicing, mitochondrial dynamics, thyroid stimulating hormone receptor agonism, inhibition of Cytochrome P450 2C19 and activation of Cytochrome P450 3A4, amongst others. It also affects multiple blood parameters (e.g., sodium, ALT, albumin, and various blood cell counts), suggesting an influence on hematological and metabolic functions. Butamben inhibits the human BSEP with an IC50 of 181100.0 nM and shows low antiviral activity against SARS-CoV-2 in various assays, including protease inhibition (24.78% at 20 µM). Moreover, it decreases sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells at 10 µM. Additionally, the compound inhibits HDAC6, with inhibition percentages of 44.45% and 12.34% in enzymatic assays. Despite its broad range of interactions with different targets, Butamben exhibits minimal direct bioactivity in most tested concentrations (AC50 > 30000.0 nM), marking it as a compound of interest for further detailed studies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
别名	Butyl 4-aminobenzoate, 4-氨基苯甲酸丁酯

化学信息

分子量	193.24
分子式	C₁₁H₁₅NO₂
CAS No.	94-25-7
Smiles	CCCCOC(=O)c1ccc(N)cc1
密度	1.078 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 36 mg/mL (186.3 mM), Sonication is recommended.

H2O: 35 mg/mL (181.12 mM), Sonication is recommended.

DMSO: 55 mg/mL (284.62 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.35 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1749 mL	25.8746 mL	51.7491 mL	258.7456 mL
5 mM	1.0350 mL	5.1749 mL	10.3498 mL	51.7491 mL
10 mM	0.5175 mL	2.5875 mL	5.1749 mL	25.8746 mL
20 mM	0.2587 mL	1.2937 mL	2.5875 mL	12.9373 mL
50 mM	0.1035 mL	0.5175 mL	1.0350 mL	5.1749 mL
100 mM	0.0517 mL	0.2587 mL	0.5175 mL	2.5875 mL