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Sulfamethizole

Name: Sulfamethizole
Brand: TargetMol
SKU: T0754
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.52%

货号 T0754Cas号 144-82-1

别名 磺胺甲噻二唑, 磺胺甲二唑, Sulfamethizol

Sulfamethizole (Sulfamethizol) 是一种磺胺噻唑类抗生素，它能抑制细菌的 PABA。

Sulfamethizole

一键复制产品信息

很棒

纯度: 99.52%

货号 T0754 别名 磺胺甲噻二唑, 磺胺甲二唑, SulfamethizolCas号 144-82-1

Sulfamethizole (Sulfamethizol) 是一种磺胺噻唑类抗生素，它能抑制细菌的 PABA。

规格	价格	库存
100 mg	¥ 115	现货
500 mg	¥ 247	现货
1 g	¥ 358	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.52%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Sulfamethizole AI Summary

Sulfamethizole exhibits multifaceted bioactivities across various biological pathways and targets. It displays significant antibacterial properties against Escherichia coli, Bacillus subtilis, and Klebsiella pneumoniae, with a dose-dependent increase in the zone of inhibition, highlighting its potency at higher concentrations. Specifically, it inhibits Escherichia coli Dihydropteroate synthase (EII50 = 0.4) and the growth of Escherichia coli (GII50 = 750.0). It also shows inhibition of Cytochrome P450 3A4 with an IC50 of 835,603.02 nM and has intrinsic solubility in water at 450.0 µg/mL. Furthermore, Sulfamethizole demonstrates a range of inhibitory activities, including Lamin A splicing, ALDH1A1, Anthrax Lethal Toxin Internalization, AmpC Beta-Lactamase, HP1-beta Chromodomain Interactions, peroxisome proliferator-activated receptor delta signaling, DNA re-replication in normal breast cells, and USP1/UAF1. It also shows potential against Plasmodium falciparum with a potency of 1,882.1 nM and inhibiting viability of multiple cancer cell lines with an IC50 of 20,000.0 nM. Additionally, it exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in various assays, though with limited efficacy indicated by hit scores and percentages. The compound has a high plasma protein binding of 93.5%, a log D distribution coefficient of -1.33 at pH 7.4, and a pKa value of 5.4. It has also demonstrated hepatotoxicity without severe liver conditions and is involved in Drug Induced Liver Injury (DILI) prediction datasets. Sulfamethizole significantly inhibits sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells, and shows weak inhibitory activity against human BSEP. Overall, Sulfamethizole exhibits extensive bioactivity with potential implications in antibacterial, antiviral, and enzymatic inhibition applications, while also showing some cytotoxic and hepatotoxic effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfamethizole (Sulfamethizol) is a sulfathiazole antibacterial reagent.
别名	磺胺甲噻二唑, 磺胺甲二唑, Sulfamethizol

化学信息

分子量	270.33
分子式	C₉H₁₀N₄O₂S₂
CAS No.	144-82-1
Smiles	S(NC=1SC(C)=NN1)(=O)(=O)C2=CC=C(N)C=C2
密度	1.562g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 45 mg/mL (166.46 mM), Sonication is recommended.

Ethanol: 10 mg/mL (36.99 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.4 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6992 mL	18.4959 mL	36.9918 mL	184.9591 mL
5 mM	0.7398 mL	3.6992 mL	7.3984 mL	36.9918 mL
10 mM	0.3699 mL	1.8496 mL	3.6992 mL	18.4959 mL
20 mM	0.1850 mL	0.9248 mL	1.8496 mL	9.2480 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0740 mL	0.3699 mL	0.7398 mL	3.6992 mL
100 mM	0.0370 mL	0.1850 mL	0.3699 mL	1.8496 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Sulfamethizole Inhibitor inhibit DHPS Bacterial Antibiotic

Sulfamethizole

Sulfamethizole

Sulfamethizole 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词