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4-Hydroxychalcone

Name: 4-Hydroxychalcone
Brand: TargetMol
SKU: T3005
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: P-Cinnamoylphenol, 4-羟基查尔酮

货号 T3005Cas号 20426-12-4 一键复制产品信息纯度: 99.75%

很棒

4-Hydroxychalcone (P-Cinnamoylphenol) 是一种查尔酮代谢物，具有抗血管生成和消炎作用。它抑制 TNF-α 诱导的 NF-κB 途径活化并激活 BMP 信号传导，通过减轻小鼠的醛固酮过多症和肾脏损伤来降低抵抗性高血压。它通过抑制生长因子途径抑制血管生成，无细胞毒性迹象。

4-Hydroxychalcone

一键复制产品信息

很棒

纯度: 99.75%

货号 T3005Cas号 20426-12-4

别名 P-Cinnamoylphenol, 4-羟基查尔酮

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
10 mg	¥ 136	现货
25 mg	¥ 197	现货
50 mg	¥ 268	现货
100 mg	¥ 380	现货
500 mg	¥ 896	现货
1 g	¥ 1,290	待询
1 mL x 10 mM (in DMSO)	¥ 170	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.75%

颜色: 白色

性状: Solid

资源下载: COA HPLC LCMS HNMR 产品操作手册

产品介绍

4-Hydroxychalcone AI Summary

4-Hydroxychalcone exhibits a diverse range of bioactivities across various biological pathways and targets. It demonstrates inhibitory effects on cell proliferation in murine P388, L1210 leukemia, human Molt 4/C8 T-lymphocyte, and Human CEM T-lymphocytes cells with IC50 values ranging from 8580.0 nM to 37900.0 nM. It induces NAD(P)H quinone reductase activity in Hepa 1c1c7 murine hepatoma cells with a CD of 33.0 µM, suggesting antioxidant or detoxifying properties. The compound also inhibits the recombinant rat androgen receptor with an IC50 of 47863.01 nM, blocks the human K+ channel in HEK293 cells with an IC50 > 50000.0 nM, and inhibits cobalt chloride-induced HIF-1 activation in mouse NIH3T3 cells with an IC50 > 20000.0 nM. 4-Hydroxychalcone exhibits antifungal activity against Candida albicans with a MIC of 62.5 µg/mL and a zone of inhibition diameter of 15.0 mm, and exhibits antifungal effects on Saccharomyces cerevisiae, Hansenula polymorpha, and Kluyveromyces lactis with MIC values > 40.0 µg/mL. It shows antibacterial activity against Staphylococcus aureus Rosenbach 209 and multidrug-resistant bacterial strains, with MIC values ranging from 32.0 µg/mL to 1000.0 µg/mL, demonstrating synergism with ciprofloxacin and doxycycline. The compound also exhibits cytotoxicity against Homo sapiens HT-29 and SGC7901 cells with IC50 values of 24600.0 nM and 13740.0 nM, respectively, and against mouse NIH/3T3 cells with less than 5.0% activity after 8 hours. 4-Hydroxychalcone shows anti-inflammatory activity by inhibiting carrageenan-induced paw edema in rats at 25 mg/kg with an inhibition of 0.165%. It inhibits TNFalpha-induced NF-kappaB activation in human A549 and K562 cells with IC50 values > 20000.0 nM and 24000.0 nM, respectively. The compound demonstrates anti-leishmanial activity against Leishmania major with an IC50 of 4000.0 nM and antioxidant activity, including DPPH radical scavenging and inhibition of bovine xanthine oxidase with IC50 values of 290000.0 nM. 4-Hydroxychalcone exhibits enzyme inhibition, notably affecting rhodanese, MDH, GroEL/GroES-mediated protein refolding, ATPase activity, and chaperone proteins such as Escherichia coli GroEL/GroES and human mitochondrial HSP60/HSP10. It inhibits PMA-induced ROS/RNS generation in human neutrophils with IC50 values of 8800.0 nM and 11600.0 nM at different glucose concentrations. Lastly, the compound also shows antidiabetic activity by decreasing glucose consumption in 3T3L1 cells, suggesting potential multifaceted therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
别名	P-Cinnamoylphenol, 4-羟基查尔酮

化学信息

分子量	224.25
分子式	C₁₅H₁₂O₂
CAS No.	20426-12-4
Smiles	OC1=CC=C(\C=C\C(=O)C2=CC=CC=C2)C=C1
密度	1.191 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

DMSO: 250 mg/mL (1114.83 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.92 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4593 mL	22.2965 mL	44.5931 mL	222.9654 mL
5 mM	0.8919 mL	4.4593 mL	8.9186 mL	44.5931 mL
10 mM	0.4459 mL	2.2297 mL	4.4593 mL	22.2965 mL
20 mM	0.2230 mL	1.1148 mL	2.2297 mL	11.1483 mL
50 mM	0.0892 mL	0.4459 mL	0.8919 mL	4.4593 mL
100 mM	0.0446 mL	0.2230 mL	0.4459 mL	2.2297 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。