Edetic acid

Name: Edetic acid
Brand: TargetMol
SKU: T20470
Price: 196 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.71%

货号 T20470Cas号 60-00-4

别名 乙二胺四乙酸, Ethylenediaminetetraacetic acid, EDTA

Edetic acid (Ethylenediaminetetraacetic acid) 是 Edetate 的酸形式，是一种具有抗高钙血症和抗凝血特性的螯合剂。它与钙和重金属离子结合后，会形成可溶的稳定复合体，使血清钙水平降低。它也可用作血液样本的抗凝剂，并用于治疗铅中毒。

Edetic acid

一键复制产品信息

很棒

纯度: 99.71%

货号 T20470 别名 乙二胺四乙酸, Ethylenediaminetetraacetic acid, EDTACas号 60-00-4

规格	价格	库存
100 mg	¥ 196	现货
500 mg	¥ 276	现货
1 g	¥ 392	现货
5 g	¥ 930	现货
10 g	¥ 1,350	现货

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纯度: 99.71%

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产品介绍

Edetic acid AI Summary

Edetic acid demonstrates various pharmacological and biological activities. It exhibits significant metal chelating and antioxidant properties, notably reducing Cu2+-amyloid beta-induced H2O2 production and Fe2+-induced hydroxyl radical formation. The compound’s potent inhibition of enzymes, including NDM-1, phosphodiesterase-1, tyrosyl-DNA phosphodiesterase, and snake venom phosphodiesterase, was observed with IC50 values in the nanomolar range. Additionally, Edetic acid shows strong antimicrobial action against methicillin-resistant Staphylococcus aureus and Candida parapsilosis in biofilm models, alongside antispasmodic action by inhibiting acetylcholine-induced contractions in guinea pig ileum. In biodistribution studies, Edetic acid predominantly accumulates in the liver of normal mice, with significant variations over time: initial high concentrations in the liver sustain and increase from 39.8% to 85.94% over 120 hours. The compound also demonstrates bioactivities such as inhibiting Cu2+-induced amyloid beta aggregation, human DNA binding to HIV-EP1, and both B. atrox and recombinant Pseudomonas aeruginosa MBL enzymes. It has shown efficiency in iron chelation, antioxidant assays, and several enzymatic inhibition tests. The compound’s human intestinal absorption rate suggests good bioavailability, and it possesses low hepatotoxicity based on DILI predictions. Finally, Edetic acid contributes to outer membrane permeabilization in Escherichia coli and Pseudomonas aeruginosa, effective against biofilm-forming and planktonic bacterial cells, and has shown antiviral potential against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Edetic acid (Ethylenediaminetetraacetic acid) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
别名	乙二胺四乙酸, Ethylenediaminetetraacetic acid, EDTA