NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration both in vitro and in vivo, accelerates liver regeneration in a mouse partial hepatectomy model, and is capable of expanding organoids derived from several mouse and human tissues.

方法：NIBR-LTSi (1，3，10μM，3天)处理人类3D皮肤模型，评估其增值作用。
结果：NIBR-LTSi处理导致角质形成细胞增殖的剂量依赖性增加，除此以外，NIBR-LTSi诱导的YAP信号传导阻碍了人角质形成细胞的分化。[1]

方法：NIBR-LTSi (30，100 mg/kg，口服)处理小鼠，研究其肝脏再生的后期阶。
结果：NIBR-LTSi在初始处理后48小时开始导致类器官的显着剂量依赖性生长并表现出成熟的足细胞标记WT1的表达降低，血清血尿素氮（BUN）的水平升高。[1]