BVT 2733

Name: BVT 2733
Brand: TargetMol
SKU: T2057
Price: 140 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.64%

货号 T2057Cas号 376640-41-4

BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病具有潜在的研究价值。

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BVT 2733

一键复制产品信息

很棒

纯度: 99.64%

货号 T2057Cas号 376640-41-4

规格	价格	库存
1 mg	¥ 140	现货
5 mg	¥ 323	现货
10 mg	¥ 535	现货
25 mg	¥ 1,070	现货
50 mg	¥ 1,770	现货
100 mg	¥ 2,560	现货
200 mg	¥ 3,580	现货
1 mL x 10 mM (in DMSO)	¥ 313	现货

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产品介绍

BVT 2733 AI Summary

BVT 2733 exhibits potent inhibition of both human and mouse 11beta-Hydroxysteroid Dehydrogenase 1 (11beta-HSD1) enzymes, with an IC50 value of 3341.0 nM for the human enzyme and 96.0 nM for the mouse enzyme, indicating significant potential for glucocorticoid modulation. It shows weak inhibition of the human 11beta-HSD2 enzyme, with an IC50 value greater than 10000.0 nM, reflecting selectivity towards 11beta-HSD1. The compound also demonstrates good oral bioavailability in mice, with an F value of 21.0%, and has a solubility of 1096500.0 nM in pH 7.4 buffer and a LogD7.4 value of 0.57, indicative of its favorable solubility and distribution properties. Furthermore, BVT 2733 shows some antiviral activity, inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells at 10 µM and exhibiting modest inhibition percentages against SARS-CoV-2 3CL-Pro protease at 20 µM. Additionally, it exhibits minor inhibition of human HDAC6 activity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
靶点活性	11β-HSD1 (human):3341 nM (IC50), 11β-HSD1 (mouse):96 nM (IC50)

化学信息

分子量	428.96
分子式	C₁₇H₂₁ClN₄O₃S₂
CAS No.	376640-41-4
Smiles	CN1CCN(CC1)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1
密度	1.427 g/cm3 (Predicted)
颜色	Red
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (139.87 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.66 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3312 mL	11.6561 mL	23.3122 mL	116.5610 mL
5 mM	0.4662 mL	2.3312 mL	4.6624 mL	23.3122 mL
10 mM	0.2331 mL	1.1656 mL	2.3312 mL	11.6561 mL
20 mM	0.1166 mL	0.5828 mL	1.1656 mL	5.8280 mL
50 mM	0.0466 mL	0.2331 mL	0.4662 mL	2.3312 mL
100 mM	0.0233 mL	0.1166 mL	0.2331 mL	1.1656 mL