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Oxindole

Name: Oxindole
Brand: TargetMol
SKU: Fr16741
Price: 113 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 板蓝根, Indolin-2-one, 2-吲哚酮

货号 Fr16741Cas号 59-48-3 一键复制产品信息纯度: 99.65%

很棒

Oxindole (Indolin-2-one) 是一种芳族杂环砌块，其衍生物是激酶抑制剂研究中的主要成分。

Oxindole

一键复制产品信息

很棒

纯度: 99.65%

货号 Fr16741Cas号 59-48-3

别名 板蓝根, Indolin-2-one, 2-吲哚酮

Oxindole (Indolin-2-one) 是一种芳族杂环砌块，其衍生物是激酶抑制剂研究中的主要成分。

规格	价格	库存
1 g	¥ 146	现货
2 g	¥ 162	现货
5 g	¥ 188	现货
10 g	¥ 272	现货
1 mL x 10 mM (in DMSO)	¥ 113	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.65%

颜色: 黄色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Oxindole AI Summary

Oxindole exhibits bioactivity influenced by its partition coefficient, with logP values varying under different conditions, suggesting different interactions with lipophilic environments. It demonstrates notable insecticidal activity against Plutella xylostella larvae (LC50 = 4832.5 ppm) and inhibits immune responses in Spodoptera exigua larvae, including hemocytic nodulation (IC50 = 32310.0 nM), phenoloxidase activity in hemolymph (IC50 = 51690.0 nM), and PLA2 activity in hemocytes (IC50 = 46250.0 nM). While it shows low potency for inhibiting recombinant human chymase (IC50 > 1000000.0 nM), it has antileishmanial activity against Leishmania infantum, affecting both axenic amastigotes and promastigotes, with notable therapeutic index values indicating relative safety and efficacy. Additionally, Oxindole inhibits human PDHK2 with an IC50 of 958,000.0 nM and exhibits some inhibitory activity against human PDHK4, with 29.0% inhibition observed relative to control..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.
别名	板蓝根, Indolin-2-one, 2-吲哚酮

化学信息

分子量	133.15
分子式	C₈H₇NO
CAS No.	59-48-3
Smiles	O=C1CC2=C(N1)C=CC=C2
密度	1.1475 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 16.67 mg/mL (125.2 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.02 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.5103 mL	37.5516 mL	75.1033 mL	375.5163 mL
5 mM	1.5021 mL	7.5103 mL	15.0207 mL	75.1033 mL
10 mM	0.7510 mL	3.7552 mL	7.5103 mL	37.5516 mL
20 mM	0.3755 mL	1.8776 mL	3.7552 mL	18.7758 mL
50 mM	0.1502 mL	0.7510 mL	1.5021 mL	7.5103 mL
100 mM	0.0751 mL	0.3755 mL	0.7510 mL	3.7552 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。