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AVP-13358

Name: AVP-13358
Brand: TargetMol
SKU: T30231
Price: 1410 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.45%

货号 T30231Cas号 459805-03-9

AVP-13358是一种CD23拮抗剂（免疫球蛋白ε-Fc 受体拮抗剂），一种免疫球蛋白E 抑制剂。AVP-13358对IgE、细胞因子和CD23有强效活性，可用于治疗免疫系统疾病、感染和耳鼻喉科疾病。

为众多的药物研发团队赋能，

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AVP-13358

一键复制产品信息

很棒

纯度: 98.45%

货号 T30231Cas号 459805-03-9

规格	价格	库存
1 mg	¥ 1,410	现货
5 mg	¥ 3,370	现货
10 mg	¥ 4,670	现货
25 mg	¥ 6,720	现货
50 mg	¥ 8,280	现货
100 mg	¥ 10,500	现货
200 mg	¥ 13,900	现货

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纯度: 98.45%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

AVP-13358 AI Summary

AVP-13358 exhibits a range of significant bioactivities and pharmacokinetic properties. It shows potent inhibition of IgE production, demonstrated ex vivo in spleen cells from antigen-sensitized BALB/c mice with an IC50 of 3.0 nM, and in B lymphocytes from BALB/c mice with an IC50 of 8.0 nM. Additionally, it inhibits the production of cytokines IL4, IL5, and IL13 in ConA and anti-CD3 antibody-sensitized BALB/c mouse spleen T lymphocytes, each with IC50 values of 30.0 nM. It also effectively suppresses CD23 expression in IL4 and anti-CD3 antibody-sensitized CD14-positive human peripheral blood lymphocytes and mouse splenocytes with IC50 values of 20.0 nM and 40.0 nM, respectively, as well as IL4 receptor alpha expression in mouse splenocytes at an IC50 of 100.0 nM. Moreover, AVP-13358 exhibits antiviral activity against HSV2, vaccinia virus, California encephalitis virus, San Angelo virus, mouse hepatitis virus, Modoc virus, and Rhinovirus-infected cells with IC50 values ranging from 20.0 nM to 300.0 nM. It also shows a favorable selectivity ratio of IC50 values for HSV2-infected and vaccinia virus-infected Vero cells compared to IgE production inhibition. Pharmacokinetically, AVP-13358 has high plasma protein binding at 99.7%, a high octan-1-ol/water distribution coefficient (LogD7.4 value of 4.24), and demonstrates high intrinsic clearance in human liver microsomes (146.0 mL.min^-1.g^-1). These properties suggest efficient liver clearance, good cellular permeability, and overall favorable pharmacokinetic characteristics. Overall, AVP-13358 presents promising potential due to its multifaceted bioactivities, particularly in antiviral effects and inhibition of IgE production..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AVP-13358 is a CD23 antagonist (immunoglobulin ε-Fc receptor antagonist), an immunoglobulin E inhibitor. AVP-13358 has potent activity against IgE, cytokines and CD23 and is used in the treatment of immune system disorders, infections and otolaryngological disorders.

化学信息

分子量	491.58
分子式	C₃₀H₂₉N₅O₂
CAS No.	459805-03-9
Smiles	C(NC1=CC=C(C=C1)C=2NC=3C(N2)=CC=C(C(NC4=CC=CC=N4)=O)C3)(=O)C56CC7CC(C5)CC(C6)C7
密度	1.38 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 7 mg/mL (14.24 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0343 mL	10.1713 mL	20.3426 mL	101.7128 mL
5 mM	0.4069 mL	2.0343 mL	4.0685 mL	20.3426 mL
10 mM	0.2034 mL	1.0171 mL	2.0343 mL	10.1713 mL

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。