Proadifen hydrochloride

Name: Proadifen hydrochloride
Brand: TargetMol
SKU: T1597
Price: 142 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.98%

货号 T1597Cas号 62-68-0

别名 盐酸丙基解痉素, U-5446, SKF-525A, RP-5171

Proadifen hydrochloride (RP-5171) 是细胞色素 P450抑制剂，它的 IC50值为19μM。

Proadifen hydrochloride

一键复制产品信息

很棒

纯度: 99.98%

货号 T1597 别名 盐酸丙基解痉素, U-5446, SKF-525A, RP-5171Cas号 62-68-0

Proadifen hydrochloride (RP-5171) 是细胞色素 P450抑制剂，它的 IC50值为19μM。

规格	价格	库存
50 mg	¥ 142	现货
100 mg	¥ 255	现货
1 mL x 10 mM (in DMSO)	¥ 150	现货

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产品介绍

Proadifen hydrochloride AI Summary

Proadifen hydrochloride exhibits a broad spectrum of bioactivities. It demonstrates potent antispasmodic activity against isolated guinea pig ileum, with an IC50 value of 0.0000012 M, and a potency relative to adiphenine of 0.62. It inhibits several enzymatic activities, such as Aryl hydrocarbon hydroxylase and Aminopyrine N-demethylase, with IC50 values of 22000.0 nM and 8200.0 nM respectively in phenobarbitone-treated rats. Additionally, it shows antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 1584.89 nM to 7943.28 nM. The compound inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected CHO cells. Furthermore, it demonstrates cytotoxicity in a HepG2 cell line with an IC50 of 57000.0 nM, and inhibits mitochondrial permeability transition pore as well as several specific enzymes and proteins, including HSD17B4, JMJD2E, TGF-b, and USP1/UAF1. Additionally, Proadifen hydrochloride activates the human and rat pregnane X receptor (PXR), inducing CYP3A4 expression in human liver cells, and exhibits antiviral activity against SARS-CoV-2 with inhibitory effects on both 3CL-Pro protease and virus-induced cytotoxicity in various cell lines. Its multifunctional bioactivities make it a potential candidate for further pharmacological investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.
靶点活性	CYP:19μM
别名	盐酸丙基解痉素, U-5446, SKF-525A, RP-5171

化学信息

分子量	389.96
分子式	C₂₃H₃₂ClNO₂
CAS No.	62-68-0
Smiles	Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (115.4 mM), Sonication is recommended.

H2O: 197.4 mM, Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.13 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5644 mL	12.8218 mL	25.6437 mL	128.2183 mL
5 mM	0.5129 mL	2.5644 mL	5.1287 mL	25.6437 mL
10 mM	0.2564 mL	1.2822 mL	2.5644 mL	12.8218 mL
20 mM	0.1282 mL	0.6411 mL	1.2822 mL	6.4109 mL
50 mM	0.0513 mL	0.2564 mL	0.5129 mL	2.5644 mL
100 mM	0.0256 mL	0.1282 mL	0.2564 mL	1.2822 mL