BS194

Name: BS194
Brand: TargetMol
SKU: T7698
Price: 793 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.85%

货号 T7698Cas号 1092443-55-4

别名 (2S,3S)-3-[[3-(异丙基)-7-[(苯基甲基)氨基]吡唑并[1,5-A]嘧啶-5-基]氨基]-1,2,4-丁三醇

BS194 是一种有效的细胞周期蛋白依赖性蛋白激酶 (CDK) 抑制剂。

为众多的药物研发团队赋能，

让新药发现更简单！

BS194

一键复制产品信息

很棒

纯度: 99.85%

货号 T7698 别名 (2S,3S)-3-[[3-(异丙基)-7-[(苯基甲基)氨基]吡唑并[1,5-A]嘧啶-5-基]氨基]-1,2,4-丁三醇Cas号 1092443-55-4

BS194 是一种有效的细胞周期蛋白依赖性蛋白激酶 (CDK) 抑制剂。

规格	价格	库存
1 mg	¥ 793	现货
5 mg	¥ 1,730	现货
10 mg	¥ 2,650	现货
25 mg	¥ 4,350	现货
50 mg	¥ 6,150	现货
100 mg	¥ 8,280	现货
1 mL x 10 mM (in DMSO)	¥ 1,890	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.85%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

BS194 AI Summary

BS194 exhibits a range of bioactivities, notably being a potent multi-targeted kinase inhibitor. It demonstrates inhibitory effects on various enzymes, including CDKs (cyclin-dependent kinases), MAPKs (mitogen-activated protein kinases), and other kinases, with competitive reversible inhibition. The most significant inhibition is observed against CDK2 (IC50 = 3.0 nM) and CDK5 (IC50 = 30.0 nM). The compound shows antiproliferative activity against various human cell lines such as MCF7, MCF10A, HCT116, A549, and HepG2, with specific cytotoxicity IC50 values of 300.0 nM for MCF7 cells and 1000.0 nM for HepG2 cells. It also demonstrates antitumor activity in xenograft mouse models and inhibits the proliferation of Plasmodium falciparum (DD2) with a potency of 8407.1 nM. Additionally, BS194 exhibits good metabolic stability, solubility, and oral bioavailability in mouse models, making it a potential candidate for developing new anticancer and antimalarial therapies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.
靶点活性	CDK7:250 nM, CDK1:30 nM, CDK9:90 nM, CDK5:30 nM, CDK2:3 nM
别名	(2S,3S)-3-[[3-(异丙基)-7-[(苯基甲基)氨基]吡唑并[1,5-A]嘧啶-5-基]氨基]-1,2,4-丁三醇

化学信息

分子量	385.46
分子式	C₂₀H₂₇N₅O₃
CAS No.	1092443-55-4
Smiles	C(C)(C)C1=C2N(C(NCC3=CC=CC=C3)=CC(N[C@H]([C@@H](CO)O)CO)=N2)N=C1
密度	1.33 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (71.34 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5943 mL	12.9715 mL	25.9430 mL	129.7151 mL
5 mM	0.5189 mL	2.5943 mL	5.1886 mL	25.9430 mL
10 mM	0.2594 mL	1.2972 mL	2.5943 mL	12.9715 mL
20 mM	0.1297 mL	0.6486 mL	1.2972 mL	6.4858 mL
50 mM	0.0519 mL	0.2594 mL	0.5189 mL	2.5943 mL