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Mebeverine hydrochloride

Name: Mebeverine hydrochloride
Brand: TargetMol
SKU: T1053
Price: 113 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 盐酸麦皮凡林, Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac Hydrochloride

货号 T1053Cas号 2753-45-9 一键复制产品信息纯度: 99.81%

很棒

Mebeverine hydrochloride (Colofac Hydrochloride) 是 β-苯乙胺的衍生物，一种增肌剂，可有效阻止肠道蠕动。它也是电压控制的钠通道 (voltage-operated sodium channels)阻断剂，抑制细胞内钙的积累。

Mebeverine hydrochloride

一键复制产品信息

很棒

纯度: 99.81%

货号 T1053Cas号 2753-45-9

别名 盐酸麦皮凡林, Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac Hydrochloride

规格	价格	库存
10 mg	¥ 113	现货
25 mg	¥ 163	现货
50 mg	¥ 263	现货
100 mg	¥ 413	现货
500 mg	¥ 997	现货
1 g	¥ 1,470	现货
1 mL x 10 mM (in DMSO)	¥ 179	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.81%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Mebeverine hydrochloride AI Summary

Mebeverine hydrochloride is involved in various bioactivities with potential therapeutic applications. It has demonstrated potency in modulating Lamin A splicing and lipid storage in Drosophila S3 cells. The compound acts as an inhibitor of AmpC Beta-Lactamase activity, Cytochrome P450 3A4 activator, and phosphatase activity of Eya2. It also shows delayed death inhibition of the malarial parasite plastid and inhibits Cell Surface uPA Generation. Additionally, Mebeverine hydrochloride induces DNA re-replication in normal breast cells and colon adenocarcinoma cells, and inhibits Hepatitis C Virus. It exhibits activity in inducing synthetic lethality in tumor cells and blocks Marburg Virus entry. The compound affects K+ channel activity and insulin secretion in INS-1E cells under different glucose conditions, and influences DNA content and chromatin condensation in HeLa cells. Notably, Mebeverine hydrochloride shows significant inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at a concentration of 10 µM, with inhibition percentages of 89.99% and 111.98%, respectively. In tests conducted on Vero E6 cells infected with SARS-CoV-2, Mebeverine hydrochloride demonstrated an inhibition index of 0.9476, indicating lower activity in inhibiting cell viability compared to the arbidol control. These bioactivities underscore Mebeverine hydrochloride's diverse, potent biological activities across different cell types and experimental conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gut.
别名	盐酸麦皮凡林, Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac Hydrochloride

化学信息

分子量	429.55
分子式	C₂₅H₃₅NO₅
CAS No.	2753-45-9
Smiles	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 252.5 mg/mL (587.82 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3280 mL	11.6401 mL	23.2802 mL	116.4009 mL
5 mM	0.4656 mL	2.3280 mL	4.6560 mL	23.2802 mL
10 mM	0.2328 mL	1.1640 mL	2.3280 mL	11.6401 mL
20 mM	0.1164 mL	0.5820 mL	1.1640 mL	5.8200 mL
50 mM	0.0466 mL	0.2328 mL	0.4656 mL	2.3280 mL
100 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1640 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。