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Diclazuril

Name: Diclazuril
Brand: TargetMol
SKU: T1172
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.58%

货号 T1172Cas号 101831-37-2

别名 地克珠利, R-64433

Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂，是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。

Diclazuril

一键复制产品信息

很棒

纯度: 98.58%

货号 T1172 别名 地克珠利, R-64433Cas号 101831-37-2

Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂，是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。

规格	价格	库存
25 mg	¥ 123	现货
50 mg	¥ 163	现货
100 mg	¥ 263	现货
200 mg	¥ 356	现货
500 mg	¥ 538	现货
1 g	¥ 868	现货
1 mL x 10 mM (in DMSO)	¥ 179	现货

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纯度: 98.58%

颜色: 白色

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COA HPLC HNMR LCMS 产品操作手册

产品介绍

Diclazuril AI Summary

Diclazuril exhibits a broad range of bioactivities. Primarily, it shows potent anti-coccidial activity against Eimeria species in both in vitro chick hepatocyte assays and in vivo 7-day coccidiosis models, with an IC50 value of 0.0008 p.p.m. and an ED95 of 1.0 p.p.m. in feed, respectively. It also inhibits second generation merozoites of Eimeria tenella, with its inhibitory activity persisting in the presence of Tranylcypromine and iproniazid. The compound's minimum effective concentration (MEC) is determined to be 0.1 p.p.m. in feed, with a Log 1/MEC value of 3.61. Additionally, Diclazuril acts as a versatile inhibitor across various biochemical assays, including inhibition of Menin-MLL interaction, GCN5L2, Histone Lysine Methyltransferase G9a, USP1/UAF1, and the vitamin D receptor (VDR). It also delays death in malarial parasites, induces DNA re-replication in MCF 10a cells, and inhibits Lassa virus binding/entry into cells. The compound activates human and rat PXR, inducing CYP3A4 expression in human HepG2 cells, with EC50 values ranging from 9000.0 nM to 35500.0 nM, and demonstrates competitive binding affinity to human PXR LBD with an EC50 of 7900.0 nM relative to SR12813. Diclazuril has antiviral activities against Influenza A virus (H1N1), showing an EC50 of 31000.0 nM in plaque reduction assays and a binding affinity to the PA cavity, with a Kd of 211000.0 nM. It also demonstrates inhibitory activity against SARS-CoV-2, with partial inhibition of the 3CL-Pro protease (25.39% at 20 µM) and inhibition of virus-induced cytotoxicity in VERO-6 cells, though IC50s are greater than 20000.0 nM. Lastly, Diclazuril exhibits strong anti-parasitic activity against Toxoplasma gondii tachyzoites, with an IC50 of 6.0 nM, and significant activity in mouse models infected with Toxoplasma gondii, achieving a 100.0% survival rate at a dose of 10 mg/kg. It also shows inhibitory activity against human HDAC6, with varying inhibition rates depending on the peptide substrate used..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Diclazuril (R-64433) is a coccidiostat.
别名	地克珠利, R-64433

化学信息

分子量	407.64
分子式	C₁₇H₉Cl₃N₄O₂
CAS No.	101831-37-2
Smiles	O=C1N(C2=CC(Cl)=C(C(C#N)C3=CC=C(Cl)C=C3)C(Cl)=C2)N=CC(=O)N1
密度	1.56 g/cm3 (Predicted)

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 18.33 mg/mL (44.97 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 1.5 mg/mL (3.68 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4531 mL	12.2657 mL	24.5314 mL	122.6572 mL
5 mM	0.4906 mL	2.4531 mL	4.9063 mL	24.5314 mL
10 mM	0.2453 mL	1.2266 mL	2.4531 mL	12.2657 mL
20 mM	0.1227 mL	0.6133 mL	1.2266 mL	6.1329 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Toxoplasma gondii Sarcocystis neurona R64433 R 64433 parasitic Parasite Inhibitor inhibit equine protozoal pyoencephalitis EPM Eimeria tenella Diclazuril coccidiosis anticoccidial agent Antibiotic ?parasite

Diclazuril

Diclazuril

Diclazuril 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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