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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Lomefloxacin

Synonyms: 洛美沙星, SC47111A
货号 T1444Cas号 98079-51-7 一键复制产品信息纯度: 99.88%
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Lomefloxacin (SC47111A) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。

Lomefloxacin

一键复制产品信息
Rating icon 很棒

纯度: 99.88%

货号 T1444Cas号 98079-51-7

别名 洛美沙星, SC47111A

Lomefloxacin (SC47111A) 是一种广谱喹诺酮类抗生素，具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。

Lomefloxacin
其他形式的 “Lomefloxacin”:
Lomefloxacin-D5 hydrochloride
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规格价格库存数量
50 mg
¥ 178
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100 mg
¥ 247
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500 mg
¥ 376
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纯度: 99.88%
颜色: 白色
性状: Solid
资源下载: COA LCMS HNMR产品操作手册

产品介绍

Lomefloxacin AI Summary
Lomefloxacin exhibits broad-spectrum antibacterial activity against both gram-negative and gram-positive bacteria, including Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa, with MIC values ranging from 0.02 to 0.1 µg/mL for some strains. It demonstrates especially strong efficacy against gram-negative organisms such as Escherichia coli and Klebsiella pneumoniae, with MIC values as low as 0.1 µg/mL. The compound also inhibits Escherichia coli DNA-gyrase and shows significant antibacterial activity against multidrug-resistant strains. Additionally, Lomefloxacin displays antimicrobial properties against various strains of Mycobacterium, including Mycobacterium tuberculosis and Mycobacterium smegmatis, with MIC values up to 10.0 µg/mL. In vitro assays have revealed moderate permeability characteristics; the compound exhibited a permeability value of 1.1 x 10^-6 cm/s in the PAMPA-BBB assay, suggesting potential ability to cross the blood-brain barrier. Pharmacokinetic studies noted high oral bioavailability of approximately 98.0% and a high volume of distribution (Vdss = 2.3 L.kg^-1). Lomefloxacin also demonstrated antitrypanosomal activity against Trypanosoma brucei brucei, with an IC50 value of 197,000.0 nM. Moreover, it showed inhibition of human enzymes such as Histone Lysine Methyltransferase G9a, Thioredoxin Reductase 1 (TrxR1), and Flap endonuclease 1 (FEN1) at sub-micromolar concentrations. However, compound 16278 exhibited phototoxic effects in UV-irradiated Swiss albino mice, with ear thickness measurements increasing after a dose of 140 mg/kg, peaking at 72 hours post-irradiation. It also demonstrated liver enzyme alterations indicative of moderate hepatotoxicity in clinical-chemistry studies. Furthermore, the compound displayed antiviral activity against SARS-CoV-2, though with moderate efficacy as indicated by its IC50 value. Overall, Lomefloxacin holds promise as a potential antimicrobial and antiparasitic agent, with noteworthy permeability and bioavailability attributes, but its phototoxic and hepatotoxic effects warrant careful consideration in further development..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
别名
洛美沙星, SC47111A
化学信息
分子量351.35
分子式C17H19F2N3O3
CAS No.98079-51-7
SmilesC(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(C2F)N3CC(C)NCC3
密度1.342 g/cm3
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMSO: 1.07 mg/mL (3.05 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.8462 mL14.2308 mL28.4616 mL142.3082 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

urinarytractTopo IVTopo IIotitismediaLomefloxacinInhibitorinhibitinfectionexternaconjunctivitisbronchitisBacterialAntibiotic
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