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Glycylglycine
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很棒货号 T5286Cas号 556-50-3
别名 双甘肽, N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, Diglycine
Glycylglycine (Diglycine) 是一种简单的多肽，能够作为谷氨酰胺 (gamma-glutamyl) 的受体。
Glycylglycine
一键复制产品信息 很棒货号 T5286 别名 双甘肽, N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, DiglycineCas号 556-50-3
Glycylglycine (Diglycine) 是一种简单的多肽，能够作为谷氨酰胺 (gamma-glutamyl) 的受体。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 mg | ¥ 108 | 现货 | |
| 1 mL x 10 mM (in H2O) | ¥ 120 | 现货 |
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产品介绍
Glycylglycine AI Summary
Glycylglycine, with a measured partition coefficient (logP) value of 3.81, is likely to be lipophilic, suggesting a higher affinity for lipid-rich regions in biological systems, which could influence its bioavailability, distribution, and metabolism. It inhibits the human intestinal peptide carrier (PEPT1) with a Ki value of 1,000,000 nM and exhibits an IC50 value of 7244359.6 nM against Angiotensin I converting enzyme, indicating potential anti-hypertensive effects. Despite low binding affinity to PEPT1 (Ki = 1,000,000 nM) in human Caco-2 cells, it shows significant bioactivity in human PEPT1 expressed in MDCK cells with an EC50 value of 480,000 nM for activation and a max activation of 112.0% relative to Gly-Sar. The compound also demonstrates binding affinity to human PepT2 in SKTP cells with Ki values around 54,000 nM, and inhibits Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells (Ki = 42,000 nM). It inhibits uptake of VACV in PEPT1-expressing CHO cells by more than 80.0%. Furthermore, Glycylglycine acts as an agonist at the PSGR/OR51E2 receptor with an EC50 value of 11,000 nM in human Hana3A cells, suggesting its potential bioactivity in modifying PSGR/OR51E2 receptor functions. Finally, it inhibits nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake by less than 15% at 5 mM after 60 seconds relative to L-citrulline..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Glycine is involved in the body's production of DNA, phospholipids, and collagen, and in the release of energy. |
| 别名 | 双甘肽, N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, Diglycine |
| 分子量 | 132.12 |
| 分子式 | C4H8N2O3 |
| CAS No. | 556-50-3 |
| Smiles | NCC(=O)NCC(O)=O |
| 密度 | 1.5851 g/cm3 (Estimated) |
| Sequence | H-Gly-Gly-OH |
| Sequence Short | GG |
| 存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: Insoluble H2O: 10 mM, Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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