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Glycylglycine

Name: Glycylglycine
Brand: TargetMol
SKU: T5286
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T5286Cas号 556-50-3

别名 双甘肽, N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, Diglycine

Glycylglycine (Diglycine) 是一种简单的多肽，能够作为谷氨酰胺 (gamma-glutamyl) 的受体。

Glycylglycine

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货号 T5286 别名 双甘肽, N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, DiglycineCas号 556-50-3

Glycylglycine (Diglycine) 是一种简单的多肽，能够作为谷氨酰胺 (gamma-glutamyl) 的受体。

规格	价格	库存	数量
100 mg	¥ 108	现货
1 mL x 10 mM (in H2O)	¥ 120	现货

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产品介绍

生物活性

产品描述	Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Glycine is involved in the body's production of DNA, phospholipids, and collagen, and in the release of energy.
别名	双甘肽, N-Glycylglycine, Gly-gly, Glycyl-glycine, Glycine dipeptide, Diglycocoll, Diglycine

化学信息

分子量	132.12
分子式	C₄H₈N₂O₃
CAS No.	556-50-3
Smiles	NCC(=O)NCC(O)=O
密度	1.5851 g/cm3 (Estimated)
颜色	White
物理性状	solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: Insoluble

H2O: 10 mM, Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	7.5689 mL	37.8444 mL	75.6888 mL	378.4438 mL
5 mM	1.5138 mL	7.5689 mL	15.1378 mL	75.6888 mL
10 mM	0.7569 mL	3.7844 mL	7.5689 mL	37.8444 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Glycylglycine, with a measured partition coefficient (logP) value of 3.81, is likely to be lipophilic, suggesting a higher affinity for lipid-rich regions in biological systems, which could influence its bioavailability, distribution, and metabolism. It inhibits the human intestinal peptide carrier (PEPT1) with a Ki value of 1,000,000 nM and exhibits an IC50 value of 7244359.6 nM against Angiotensin I converting enzyme, indicating potential anti-hypertensive effects. Despite low binding affinity to PEPT1 (Ki = 1,000,000 nM) in human Caco-2 cells, it shows significant bioactivity in human PEPT1 expressed in MDCK cells with an EC50 value of 480,000 nM for activation and a max activation of 112.0% relative to Gly-Sar. The compound also demonstrates binding affinity to human PepT2 in SKTP cells with Ki values around 54,000 nM, and inhibits Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells (Ki = 42,000 nM). It inhibits uptake of VACV in PEPT1-expressing CHO cells by more than 80.0%. Furthermore, Glycylglycine acts as an agonist at the PSGR/OR51E2 receptor with an EC50 value of 11,000 nM in human Hana3A cells, suggesting its potential bioactivity in modifying PSGR/OR51E2 receptor functions. Finally, it inhibits nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake by less than 15% at 5 mM after 60 seconds relative to L-citrulline..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl