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Monobenzone

Name: Monobenzone
Brand: TargetMol
SKU: T0759
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: Benoquin, 4-苄氧基苯酚

货号 T0759Cas号 103-16-2 一键复制产品信息纯度: 99.87%

很棒

Monobenzone (Benoquin) 是皮肤脱色剂。它可引起色素脱失和活跃的人白癜风，对白癜风具有潜在的研究价值。

Monobenzone

一键复制产品信息

很棒

纯度: 99.87%

货号 T0759Cas号 103-16-2

别名 Benoquin, 4-苄氧基苯酚

Monobenzone (Benoquin) 是皮肤脱色剂。它可引起色素脱失和活跃的人白癜风，对白癜风具有潜在的研究价值。

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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实验操作小课堂

常见问题解答

选择批次:

纯度: 99.87%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR HPLC 产品操作手册

产品介绍

Monobenzone AI Summary

Monobenzone exhibits a diverse range of bioactivities and inhibitory properties across multiple biological targets. It has a significant inhibitory effect on the recombinant rat androgen receptor expressed in Escherichia coli with an IC50 value of 234422.88 nM. The compound shows potent modulation of Lamin A splicing, induces erasure of genomic imprints with moderate potency, and has both inhibitory and potential substrate activity towards Cytochrome P450 2C19. Additionally, Monobenzone displays agonistic and antagonistic activities in the Hypoxia Response Element signaling pathway and has been identified as a potential novel general anesthetic. In various enzyme inhibition assays, Monobenzone exhibits inhibition of COX-1 (IC50: 1019.0 nM), COX-2 (IC50: 3726.0 nM), Lipoxygenase 15-LO (IC50: 4892.0 nM), and Norepinephrine Transporter with an IC50 value of 3886.0 nM and a Ki value of 3854.0 nM. However, it shows no significant hepatic toxicity based on the Drug Induced Liver Injury Prediction System (DILIps). Monobenzone is active in assays related to Cytochrome P450 isoforms including p450-cyp2c19 and p450-cyp1a2 and demonstrates moderate inhibition of the malarial parasite plastid. It also has activity in Schwann cell assays, inhibits human tyrosyl-DNA phosphodiesterase 1, affects Plasmodium falciparum proliferation, and interferes with the binding or cellular entry of the Lassa and Ebola viruses. In the context of SARS-CoV-2, Monobenzone shows low bioactivity in inhibiting cell viability of Vero E6 cells infected with the virus, with inhibition percentages and IC50 values below the thresholds of significant activity. However, it does exhibit inhibitory activity against the SARS-CoV-2 3CL-Pro protease with a modest inhibition percentage. Notably, Monobenzone demonstrates potent inhibitory activity against human HDAC6 in various enzymatic assays, with inhibition percentages of 98.06%, 87.0%, and 86.56%, and an IC50 value of 988.8 nM with a custom peptide substrate, underscoring its high potency and selectivity as an HDAC6 inhibitor. Additionally, the compound binds to human SLC6A3 and SLC6A2 with AC50 values of 8556.0 nM and 6955.0 nM, respectively, and inhibits human PTGS1 with AC50 values measured at 10953.4 nM and 7876.3 nM through different detection methods..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Monobenzone (Benoquin) is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting Activity.
别名	Benoquin, 4-苄氧基苯酚

化学信息

分子量	200.23
分子式	C₁₃H₁₂O₂
CAS No.	103-16-2
Smiles	OC1=CC=C(OCC2=CC=CC=C2)C=C1
密度	1.26

储存&溶解度

存储

溶解度信息

Ethanol: 38 mg/mL (189.78 mM), Sonication is recommended.

DMSO: 45 mg/mL (224.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.99 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9943 mL	24.9713 mL	49.9426 mL	249.7128 mL
5 mM	0.9989 mL	4.9943 mL	9.9885 mL	49.9426 mL
10 mM	0.4994 mL	2.4971 mL	4.9943 mL	24.9713 mL
20 mM	0.2497 mL	1.2486 mL	2.4971 mL	12.4856 mL
50 mM	0.0999 mL	0.4994 mL	0.9989 mL	4.9943 mL
100 mM	0.0499 mL	0.2497 mL	0.4994 mL	2.4971 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

vitiligo Tyrosinase skin Monobenzone Inhibitor inhibit depigmenting depigmentation

Monobenzone

Monobenzone

Monobenzone 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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