Prazosin

Name: Prazosin
Brand: TargetMol
SKU: T22406
Rating: 4.5 (1 reviews)

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很棒

纯度: 99.86%

货号 T22406Cas号 19216-56-9

别名 哌唑嗪, Prazosine, Prazocin, Furazosin

Prazosin (Prazosine) 是一种 α1 受体阻滞剂，是一种 α1 肾上腺素能受体的反向激动剂，用于治疗高血压。

Prazosin

一键复制产品信息

很棒

纯度: 99.86%

货号 T22406 别名 哌唑嗪, Prazosine, Prazocin, FurazosinCas号 19216-56-9

Prazosin (Prazosine) 是一种 α1 受体阻滞剂，是一种 α1 肾上腺素能受体的反向激动剂，用于治疗高血压。

规格	价格	库存
5 mg	¥ 255	5日内发货
50 mg	¥ 946	5日内发货
100 mg	¥ 1,450	5日内发货
1 mL x 10 mM (in DMSO)	¥ 248	现货

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产品介绍

Prazosin AI Summary

Prazosin exhibits strong alpha-1 adrenergic receptor antagonism with a very high binding affinity, demonstrated by Ki values ranging from 0.19 nM to 0.32 nM across different assays. It shows a significantly lower affinity for the alpha-2 adrenergic receptor, with Ki values up to 4830.0 nM. This compound is highly selective for alpha-1 receptors over alpha-2 receptors, indicated by a selectivity ratio of around 1258.9. Prazosin effectively reduces blood pressure in spontaneously hypertensive rats, showing dose-dependent antihypertensive activity with a maximum reduction of 45.0 mmHg at an oral dose of 30 mg/kg. It also exhibits significant vasorelaxant activity, blocking norepinephrine-induced contractions in rat and rabbit arterial tissues. Furthermore, Prazosin demonstrates robust antagonist activity in various adrenergic subtypes, notably alpha-1A, alpha-1B, and alpha-1D adrenergic receptors. Along with the cardiovascular functions, it also shows potential in modulating neurotransmitter responses, given its efficacy in displacing radioligands like [3H]prazosin from rat cerebral cortex membranes and displaying antagonist activity at the dopamine D2 receptors. Prazosin's effective oral bioavailability and selective inhibition properties make it a promising candidate for addressing cardiovascular conditions such as hypertension..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.
别名	哌唑嗪, Prazosine, Prazocin, Furazosin

化学信息

分子量	383.4
分子式	C₁₉H₂₁N₅O₄
CAS No.	19216-56-9
Smiles	NC=1C2=C(N=C(N1)N3CCN(C(=O)C4=CC=CO4)CC3)C=C(OC)C(OC)=C2
密度	1.352g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (130.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.04 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6082 mL	13.0412 mL	26.0824 mL	130.4121 mL
5 mM	0.5216 mL	2.6082 mL	5.2165 mL	26.0824 mL
10 mM	0.2608 mL	1.3041 mL	2.6082 mL	13.0412 mL
20 mM	0.1304 mL	0.6521 mL	1.3041 mL	6.5206 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6082 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3041 mL