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Cromoglicic acid

Name: Cromoglicic acid
Brand: TargetMol
SKU: T8239
Price: 199 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.55%

货号 T8239Cas号 16110-51-3

别名 色甘酸

Cromoglicic acid 可防止肥大细胞释放炎性化学物质，例如组胺。

Cromoglicic acid

一键复制产品信息

很棒

纯度: 99.55%

货号 T8239 别名 色甘酸Cas号 16110-51-3

Cromoglicic acid 可防止肥大细胞释放炎性化学物质，例如组胺。

规格	价格	库存
5 mg	¥ 99	现货
10 mg	¥ 149	现货
25 mg	待询	现货
1 mL x 10 mM (in DMSO)	¥ 199	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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纯度: 99.55%

颜色: 白色

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资源下载:

COA LCMS HPLC HNMR 产品操作手册

产品介绍

Cromoglicic acid AI Summary

Cromoglicic acid is a compound with multifaceted bioactivities and properties, showcasing potential in various biological contexts. It has a binding constant of Log K' = 1.07 against human serum albumin (HSA), suggesting its ability to bind and be transported by this protein in the body. It is highly acidic with pKa values below 2.0 and exhibits a dissociation constant (pKa) of 1.9. In human pharmacokinetics, it demonstrates a fraction unbound in plasma logFu of 0.0 and a volume of distribution at steady state (Vdss) of 0.32 L.kg-1, with an unbound Cmax of 0.192 µM. Cromoglicic acid also displays bioactivities as an inhibitor of: - Lamin A splicing (potency: 707.9 nM). - Tyrosyl-DNA Phosphodiesterase (TDP1) (potency: 1778.3 nM). - Various viral activities, including Marburg Virus, Lassa Virus, and SARS-CoV-2, although with varying potencies for each virus. - Plasmodium falciparum proliferation (potency ranging from 0.7 to 37.6 nM). - Human Apurinic/apyrimidinic Endonuclease 1 (APE1) (potency: 631.0 nM). In addition to these bioactivities, Cromoglicic acid acts as an agonist at human GPR35, showing EC50 values in various assays, such as 210.0 nM in Ca+2 release and 520.0 nM in DMR assays. It exhibits a competitive binding affinity to Nluc-fused human GPR35 with a Ki value of 2970.0 nM. Regarding safety and absorption, Cromoglicic acid has a hepatic side effect (HepSE) score of 1.0, indicating a risk for liver disease, without observable acute hepatotoxicity. It is moderately absorbed in the human intestine with a log10(%HIA) of approximately 1.021 and shows minimal inhibition of the Bile Salt Export Pump (BSEP), with an IC50 value greater than 1,000,000 nM. Cromoglicic acid also impacts various biological parameters, influencing liver enzymes, kidney function markers, electrolytes, cholesterol levels, and blood cell parameters, suggesting potential influences on liver, kidney, cardiovascular, and hematological functions. Overall, Cromoglicic acid presents as a molecule with significant acid-base properties, diverse bioactivities including antiviral, antiparasitic, enzymatic inhibition, and receptor agonism, and some potential for liver-related side effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.
别名	色甘酸

化学信息

分子量	468.37
分子式	C₂₃H₁₆O₁₁
CAS No.	16110-51-3
Smiles	OC(COc1cccc2oc(cc(=O)c12)C(O)=O)COc1cccc2oc(cc(=O)c12)C(O)=O
密度	1.623

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 20.8 mg/mL (44.41 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1351 mL	10.6753 mL	21.3506 mL	106.7532 mL
5 mM	0.4270 mL	2.1351 mL	4.2701 mL	21.3506 mL
10 mM	0.2135 mL	1.0675 mL	2.1351 mL	10.6753 mL
20 mM	0.1068 mL	0.5338 mL	1.0675 mL	5.3377 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit Cromolyn Cromoglicic acid cell stabilizer bronchial asthma allergic rhinitis allergic eye

Cromoglicic acid

Cromoglicic acid