store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OD36 是一种选择性强效 RIPK2 抑制剂,IC50 为 5.3 nM。OD36 可抑制 ALK2 信号传导和成骨分化(KD:37 nM),并能与 ALK2 激酶 ATP 袋有效结合。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 412 | 现货 | ||
2 mg | ¥ 598 | 现货 | ||
5 mg | ¥ 993 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 2,480 | 现货 | ||
50 mg | ¥ 3,730 | 现货 |
产品描述 | OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket. |
靶点活性 | ALK2:37 nM (Kd), ALK2:47 nM (IC50), RIPK2:5.3 nM (IC50), ALK2 (R206H):22 nM (IC50) |
体外活性 |
OD36 shows activity against ALK1 (KD=90 nM).[2] OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation.[2] OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5.[2] OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).[2] |
体内活性 | OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression. OD36 alleviates inflammation in an acute peritonitis mice model.[3] |
别名 | OD 36, OD 36 hydrochloride, OD-36 |
分子量 | 330.77 |
分子式 | C16H15ClN4O2 |
CAS No. | 1638644-62-8 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (75.58 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0232 mL | 15.1162 mL | 30.2325 mL | 75.5812 mL |
5 mM | 0.6046 mL | 3.0232 mL | 6.0465 mL | 15.1162 mL | |
10 mM | 0.3023 mL | 1.5116 mL | 3.0232 mL | 7.5581 mL | |
20 mM | 0.1512 mL | 0.7558 mL | 1.5116 mL | 3.7791 mL | |
50 mM | 0.0605 mL | 0.3023 mL | 0.6046 mL | 1.5116 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
OD36 1638644-62-8 Angiogenesis Apoptosis NF-Κb Tyrosine Kinase/Adaptors ALK RIP kinase OD 36 OD36 Hydrochloride OD 36 Hydrochloride OD 36 hydrochloride OD-36 Hydrochloride OD-36 Inhibitor inhibitor inhibit