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Sulfameter

Name: Sulfameter
Brand: TargetMol
SKU: T0748
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.90%

货号 T0748Cas号 651-06-9

别名 磺胺对甲氧嘧啶, Sulfametoxydiazine, 5-Methoxysulfadiazine

Sulfameter (Sulfametoxydiazine) 是一种长效磺胺类抗生素，具有抗菌活性。它可研究尿路感染和麻风病。

Sulfameter

一键复制产品信息

很棒

纯度: 99.90%

货号 T0748 别名 磺胺对甲氧嘧啶, Sulfametoxydiazine, 5-MethoxysulfadiazineCas号 651-06-9

Sulfameter (Sulfametoxydiazine) 是一种长效磺胺类抗生素，具有抗菌活性。它可研究尿路感染和麻风病。

规格	价格	库存
1 g	¥ 123	现货
5 g	¥ 247	现货
10 g	¥ 396	待询
1 mL x 10 mM (in DMSO)	¥ 135	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.90%

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COA HNMR LCMS 产品操作手册

产品介绍

Sulfameter AI Summary

Sulfameter demonstrates a range of bioactivities with notable potencies across various assays. It is a potent inducer of genomic imprint erasure (3162.3 nM), DNA re-replication in MCF 10a breast cells (20.6 nM), and TGF-b activity inhibition (112.2 nM). Furthermore, it exhibits inhibitory effects against Lamin A splicing (12589.3 nM), AmpC Beta-Lactamase (354.8 nM), Hepatitis C Virus (35481.3 nM), Plasmodium falciparum proliferation (0.9 nM), PTHR (10000.0 nM), and Ebola virus entry (AC50 of 8912.5 nM). The compound has a log P value of 0.46 and an intrinsic solubility log 1/S0 value of 3.63. It also impacts sodium fluorescein uptake in OATP1B3 (112.86%) and OATP1B1 (233.46%) transfected CHO cells at 10 µM, indicating potential effects on transporter functions. Moderate liver toxicity is observed with choleostatic liver toxicity and a low percentage of acute liver toxicity noted in clinical trials, but without significant cytolytic, chronic, or severe liver toxicity indications. Against SARS-CoV-2, Sulfameter shows limited efficacy. It does not inhibit cell viability of infected Vero E6 cells and demonstrates varying levels of low antiviral activity in different assays. It inhibits SARS-CoV-2 3CL-Pro protease by 24.24% at 20 µM, but other assays reflect poor inhibition with IC50 values exceeding 20000.0 nM. In specific assays, it showed -1.71% and -0.16% inhibition of cytotoxicity in Caco-2 and Vero-6 cells, respectively, at 10 µM. Additionally, Sulfameter shows minor inhibitory activity on the human HDAC6 enzyme, with 11.53% inhibition in one assay and 0.35% in another..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.
别名	磺胺对甲氧嘧啶, Sulfametoxydiazine, 5-Methoxysulfadiazine

化学信息

分子量	280.3
分子式	C₁₁H₁₂N₄O₃S
CAS No.	651-06-9
Smiles	S(NC=1N=CC(OC)=CN1)(=O)(=O)C2=CC=C(N)C=C2
密度	1.465 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (214.06 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.14 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5676 mL	17.8380 mL	35.6761 mL	178.3803 mL
5 mM	0.7135 mL	3.5676 mL	7.1352 mL	35.6761 mL
10 mM	0.3568 mL	1.7838 mL	3.5676 mL	17.8380 mL
20 mM	0.1784 mL	0.8919 mL	1.7838 mL	8.9190 mL
50 mM	0.0714 mL	0.3568 mL	0.7135 mL	3.5676 mL
100 mM	0.0357 mL	0.1784 mL	0.3568 mL	1.7838 mL