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ICA 110381

Name: ICA 110381
Brand: TargetMol
SKU: T7612
Price: 143 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T7612Cas号 325457-99-6 一键复制产品信息纯度: 97.72%

很棒

ICA 110381 是一种KCNQ2/Q3钾通道开放剂，有潜力用于癫痫的研究。ICA 110381 是KCNQ2/Q3激动剂 (EC50=0.38 μM) 以及KCNQ1拮抗剂 (IC50=15 μM)。

ICA 110381

一键复制产品信息

很棒

纯度: 97.72%

货号 T7612Cas号 325457-99-6

ICA 110381 是一种KCNQ2/Q3钾通道开放剂，有潜力用于癫痫的研究。ICA 110381 是KCNQ2/Q3激动剂 (EC50=0.38 μM) 以及KCNQ1拮抗剂 (IC50=15 μM)。

规格	价格	库存
5 mg	¥ 148	现货
10 mg	¥ 208	现货
25 mg	¥ 355	现货
50 mg	¥ 522	现货
100 mg	¥ 708	现货
1 mL x 10 mM (in DMSO)	¥ 143	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 97.72%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

ICA 110381 AI Summary

ICA 110381 exhibits both agonist and antagonist activities depending on the target and the cell line used. It acts as an agonist at KCNQ2/KCNQ3 channels expressed in CHO cells, increasing KCl-induced ^86Rb^+ efflux with an EC50 of 380.0 nM. Conversely, it shows antagonist activity at KCNQ1/MINK channels in CHO cells, inhibiting the same efflux with an IC50 of 15000.0 nM. In terms of antiviral activity, ICA 110381 demonstrates inhibition of SARS-CoV-2 induced cytotoxicity. It reduces cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours with an inhibition rate of 9.51%. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease by 10.33% at 20 µM concentration, indicating potential relevance in targeting viral replication. When tested on VERO-6 cells, it shows a slightly negative inhibition rate (-0.1%) at 10 µM concentration after 48 hours, suggesting variable efficacy depending on the cell line. ICA 110381 also exhibits inhibitory activity against the human HDAC6 enzyme, showing 27.13% inhibition in an enzymatic assay using a commercial peptide substrate and 19.84% inhibition using a custom peptide substrate. Regarding its effects on cell viability, ICA 110381 shows a range of growth rates: in HEK293T cells, it varies from 0.16 to 0.71, suggesting moderate impact on proliferation. In U2OS cells, it consistently suppresses growth (-0.12 to -0.39). In human fibroblasts, the compound demonstrates a mixed impact on cell viability, with growth rates ranging from -0.9 to 0.54, highlighting its complex bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy
靶点活性	KCNQ1:15 μM, KCNQ2/Q3:0.38 μM(EC50)

化学信息

分子量	267.11
分子式	C₁₂H₈Cl₂N₂O
CAS No.	325457-99-6
Smiles	C(NC=1C=CC(Cl)=NC1)(=O)C2=CC=C(Cl)C=C2
密度	1.440 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 14 mg/mL (52.41 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7438 mL	18.7189 mL	37.4378 mL	187.1888 mL
5 mM	0.7488 mL	3.7438 mL	7.4876 mL	37.4378 mL
10 mM	0.3744 mL	1.8719 mL	3.7438 mL	18.7189 mL
20 mM	0.1872 mL	0.9359 mL	1.8719 mL	9.3594 mL
50 mM	0.0749 mL	0.3744 mL	0.7488 mL	3.7438 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。