Name: Duloxetine
Brand: TargetMol
SKU: T7061
Price: 139 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 139

现货

5 mg

¥ 279

现货

10 mg

¥ 393

现货

25 mg

¥ 658

现货

50 mg

¥ 892

现货

100 mg

¥ 1,180

现货

200 mg

¥ 1,750

现货

1 mL x 10 mM (in DMSO)

¥ 293

现货

产品介绍

生物活性

产品描述	Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
靶点活性	5-HT-Norepinephrine reuptake:4.6 nM(ki)
体外活性	IC50 of duloxetine for the resting and inactivated wild-type hNav1.7 Na+ channel were 22.1+/-0.4 and 1.79+/-0.10 microM, respectively (mean+/-SE, n=5).?The IC50 for the open Na+ channel was 0.25+/-0.02 microM (n=5), as determined by the block of persistent late Nav1.7 Na+ currents.?Similar open-channel block by duloxetine was found in the muscle Nav1.4 isoform (IC50=0.51+/-0.05 microM;?n=5).?Block by duloxetine appeared via the conserved local anesthetic receptor as determined by site-directed mutagenesis.?Finally, duloxetine elicited strong use-dependent block of neuronal transient Nav1.7 Na+ currents during repetitive stimulations[1].
细胞实验	Used the whole cell, patch clamp technique to test whether duloxetine interacts with the neuronal Nav1.7 Na+ channel as a potential target.?Resting and inactivated Nav1.7 Na+ channel block by duloxetine were measured by conventional pulse protocols in transfected human embryonic kidney cells.?The open-channel block was determined directly using inactivation-deficient mutant Nav1.7 Na+ channels[1].
别名	度洛西汀

化学信息

分子量	297.41
分子式	C₁₈H₁₉NOS
CAS No.	116539-59-4
Smiles	CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
密度	1.158 g/cm3
颜色	Yellow
物理性状	Oil

储存&溶解度

存储

store at low temperature,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 40 mg/mL (134.49 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 4 mg/mL (13.45 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3624 mL	16.8118 mL	33.6236 mL	168.1181 mL
5 mM	0.6725 mL	3.3624 mL	6.7247 mL	33.6236 mL
10 mM	0.3362 mL	1.6812 mL	3.3624 mL	16.8118 mL
20 mM	0.1681 mL	0.8406 mL	1.6812 mL	8.4059 mL
50 mM	0.0672 mL	0.3362 mL	0.6725 mL	3.3624 mL
100 mM	0.0336 mL	0.1681 mL	0.3362 mL	1.6812 mL

体内实验配液计算器