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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Diiodohydroxyquinoline

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纯度: 97.74%

货号 T0513Cas号 83-73-8

别名 双碘喹, Iodoquinol, 5,7-Diiodo-8-quinolinol, 5,7-Diiodo-8-hydroxyquinoline

Diiodohydroxyquinoline (Iodoquinol) 有较好的抗菌作用。

Diiodohydroxyquinoline

Diiodohydroxyquinoline

一键复制产品信息
Rating icon 很棒

纯度: 97.74%

货号 T0513 别名 双碘喹, Iodoquinol, 5,7-Diiodo-8-quinolinol, 5,7-Diiodo-8-hydroxyquinolineCas号 83-73-8

Diiodohydroxyquinoline (Iodoquinol) 有较好的抗菌作用。

规格价格库存数量
500 mg
¥ 163
现货
1 g
¥ 247
现货
5 g
¥ 496
现货
1 mL x 10 mM (in DMSO)
¥ 179
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产品介绍

Diiodohydroxyquinoline AI Summary
Diiodohydroxyquinoline demonstrates a broad spectrum of bioactivities, indicating its potential as a versatile bioactive substance. It exhibits moderate to high potency as an inhibitor of various enzymes and pathways, including Lamin A Splicing, HSD17B4, JMJD2E, SMN2 Splice Variant Expression, TDP1, and ERK Signaling Pathway. Additionally, it shows potency in cell models for conditions such as Huntington's disease, Stat Signaling, Genomic imprint erasure, and Aldehyde Dehydrogenase 1 inhibition. Diiodohydroxyquinoline also affects cytotoxicity and cell viability in different cell lines, including HPDE-C7, HPDE-C7K, p53 mutant cancer cells, and during an influenza NS1 Protein Function assay. Notably, it inhibits various protein functions such as 15-hLO, ROR gamma transcriptional activity, Menin-MLL Interaction, and Tyrosyl-DNA phosphodiesterase 1. The compound shows activity in inducing DNA re-replication, disrupting protein interactions, and inhibiting malarial parasite functions and cancer cells with p53 mutations. It also inhibits several kinases, including ERK1, ERK2, p38alpha, EGF Receptor, Fyn, ERBB2 (HER2), and LCK with varying IC50 values. Moreover, Diiodohydroxyquinoline inhibits the OATP1B1 and OATP1B3 transporters, catechol-O-methyltransferase (COMT), and human BSEP. It shows antiviral activity against SARS-CoV-2 and antitrypanosomal activity against Trypanosoma brucei brucei. Additionally, it has antifungal activity against Candida albicans and Cryptococcus neoformans, antibacterial activity against Escherichia coli and other bacteria, and slight inhibition of human HDAC6 activity. The compound's solubility and permeability characteristics are suggested by its LogD7.4 value of 2.19, and it also shows haemolysis of human Red Blood Cells and cytotoxicity against HEK293 and HepG2 cells. Overall, Diiodohydroxyquinoline interacts with a variety of receptors and enzymes, suggesting its role as a multi-target bioactive compound..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Diiodohydroxyquinoline (Iodoquinol), a topical therapeutic agent, has satisfactory antibacterial properties.
别名双碘喹, Iodoquinol, 5,7-Diiodo-8-quinolinol, 5,7-Diiodo-8-hydroxyquinoline
化学信息
分子量396.95
分子式C9H5I2NO
CAS No.83-73-8
SmilesOc1c(I)cc(I)c2cccnc12
密度2.3013 g/cm3 (Estimated)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 6.25 mg/mL (15.75 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.5192 mL12.5960 mL25.1921 mL125.9604 mL
5 mM0.5038 mL2.5192 mL5.0384 mL25.1921 mL
10 mM0.2519 mL1.2596 mL2.5192 mL12.5960 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

InhibitorinhibitDiiodohydroxyquinolineBacterialAntibiotic
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